Investigating the effect of positron emitter of 18F-FDG dose and the body mass index on the detectability of liver cancer using PET-CT scanner | ||
| Arab Journal of Nuclear Sciences and Applications | ||
| Volume 58, Issue 4, October 2025, Pages 75-84 PDF (743.79 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ajnsa.2025.410135.1895 | ||
| Authors | ||
| Mahmoud Mizar* 1; Yasser Abd Elqawy2; Goncalo Ferreira3; Yasser Y Ebaid4; Tarek Ahmed Mohamed5 | ||
| 1Department of Physics, Faculty of Science, Fayoum University, Fayoum, Egypt. Department of Nuclear Medicine, Masria Scan Centers, Beni Suef & Cairo, Egypt. Department of Nuclear Medicine, Burjeel Medical City, Abu-Dhabi, UAE. | ||
| 2Department of Physics, Faculty of Science, Fayoum University, Fayoum, Egypt | ||
| 3Department of Nuclear Medicine, Burjeel Medical City, Abu-Dhabi, UAE | ||
| 4Physics Department, Faculty of Science, Fayoum University, Fayoum, EGYPT | ||
| 5Faculty of Science , Physics Department, Fayoum University, Fayoum, Egypt. | ||
| Abstract | ||
| Accurate image quality is critical for the effective detection of hepatic malignancies using PET/CT imaging. This study investigates the impact of body mass index (BMI) and fluorine-18 fluorodeoxyglucose (¹⁸F-FDG) dose on image quality, quantified through the signal-to-noise ratio (SNR), in liver cancer patients undergoing PET/CT scans. Seventy-five patients (32 males, 43 females) were categorized into normal weight, overweight, and obese groups based on BMI. PET/CT imaging was performed using a Discovery IQ scanner following intravenous administration of ¹⁸F-FDG, with two dosing protocols: 0.1 mCi/kg and a reduced dose of 0.05 mCi/kg. Acquisition times varied between 1 to 3 minutes per bed position, adjusted according to body habitus and dose. The study demonstrated a clear inverse correlation between BMI and SNR, with obese patients showing the lowest SNR values. Patients receiving the lower 0.05 mCi/kg dose exhibited significantly reduced SNRs when imaged for only 1.5 minutes per bed. However, extending acquisition time to 3 minutes per bed restored image quality to levels comparable to those receiving 0.1 mCi/kg for 1.5 minutes. These findings highlight the effectiveness of dose-time compensation strategies in preserving image quality while minimizing radiation exposure. In conclusion, PET/CT image quality is significantly influenced by BMI and injected dose. Optimization of scan duration based on patient-specific parameters can mitigate degradation in image clarity, supporting the feasibility of personalized imaging protocols to improve diagnostic outcomes and reduce radiation burden. | ||
| Keywords | ||
| Positron Emission Tomography (PET/CT); ¹⁸F-FDG; Body Mass Index (BMI); Signal-to-Noise Ratio (SNR); Liver Cancer Imaging; Dose-Time Optimization; Image Quality; Radiation Dose Reduction; PET Image Reconstruction; Diagnostic Performance | ||
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