Impact of End-Stage Renal Disease on Ventilatory Function and Functional Capacity in Children | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 32, Volume 101, Issue 1, October 2025, Pages 4807-4812 PDF (811.16 K) | ||
| DOI: 10.21608/ejhm.2025.456831 | ||
| Abstract | ||
| Background: End-stage renal disease (ESRD) is the last stage of chronic kidney disease (CKD), as the kidneys are not able to function on their own. Children at this stage have deterioration in mechanical and ventilatory functions of the lungs as the air flow is affected by the drugs and hemodialysis. The physiology of the lung is also altered by the disease as it changes the fluid homeostasis, acid-base stability and tone of vessels. The disturbances in lung and hemodynamic causes changes in ventilatory regulation, pulmonary congestion, capillary stress-induced damage, and pulmonary vascular disorders. Objective: This study aimed to detect the effect of CKD on lung functions and functional capacity and to investigate the relation between functional capacity and ventilatory functions in children at ESRD subjected to dialysis. Methods: Twenty-one children at ESRD treated with dialysis with an age range from six to fifteen years were selected from Zagazig University Hospitals. They were subdivided according to their age into two groups (group 1 with age ranged from 6 to 10 years and group 2 with age range from eleven to fifteen years) in addition to twenty-one age-matched normal healthy children participated in the current study. Ventilatory functions and functional capacity were measured for all children by using a computerized spirometer and 6-minute walk test (6MWT) respectively. Results: Bivariate Spearman correlation coefficients were computed between functional capacities with ventilatory functions for children in the age-matched groups. The results revealed a statistically significant positive correlation between functional capacity with ventilatory functions in both age strata in the normal group but in ESRD children, there was positive non-significant correlation between 6 MWT with ventilatory functions in both age strata. There was a statistically significant difference between the studied groups regarding the 6MWT, MVV, FVC, FEV1, and PEF (all were significantly higher among the normal group). Conclusions: There was significantly positive correlation between ventilatory functions and functional capacity in normal children, while in ESRD children the correlation was not statistically significant. | ||
| Keywords | ||
| Children; ESRD; Functional capacity; Ventilatory functions | ||
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