The Effects of Matcha Green Tea Extract (Camellia sinensis L.) on Insulin Resistance and Oxidative Stress in Steatohepatitis Rats | ||
| مجلة الاقتصاد المنزلي | ||
| Volume 41, Issue 4, December 2025, Pages 121-142 PDF (466.88 K) | ||
| Document Type: المقالة الأصلية | ||
| DOI: 10.21608/jhe.2025.456916 | ||
| Authors | ||
| Esraa Rafat Elharoon1; Hany Gaber EL-Masry1; Shaimaa H. Negm2 | ||
| 1Nutrition and Food Science Department, Faculty of Home Economics, Helwan University | ||
| 2Home Economics Dept., Specific Education Faculty, Port Said University, Egypt | ||
| Abstract | ||
| This study was conducted to investigate the effects of matcha green tea (Camellia sinensis L.) aqueous extract (MGTE) on insulin resistance and oxidative stress in steatohepatitis rats. Thirty-five male albino rats weighting (150± 10 g.) were randomly divided into two main groups as follows: Group 1 (n=7 as negative group) was fed a basal diet; Group 2 (n=35) was fed on high fat diet (HFD) deficient in methionine and choline, for induction of steatohepatitis. After induction, rats reclassified into 4 equal groups as following: subgroup 1 kept as positive group, while the other three groups were fed on HFD and received (MGTE) as 1, 2, 3 ml/rats/day by gavage, respectively. Results revealed that the rats in all the groups, except for the control group, exhibited significant weight loss and improve leptin levels as compared to positive control group. Furthermore, (MGTE) consumption led to an improvement in the biochemical changes resulting from steatohepatitis in rats through improve blood glucose, insulin levels, , insulin resistance, levels of liver (ALT, AST, ALP), kidney function levels of (urea, creatinine and uric acid) as well as in lipid profile, while were recorded a significant increase in a high-density lipoprotein-cholesterol (HDL-C). In addition antioxidants enzymes (SOD, CAT and GPX) were significantly (P<0.05) increased while, significantly reduced MDA as compared to the positive control group. In conclusion, matcha green tea extract alleviated steatohepatitis in rats via suppression of insulin resistance, hyperglycemia, hyperlipidemia, and oxidative stress, due to their containing phenolic compounds. | ||
| Keywords | ||
| (Camellia sinensis L.); Insulin resistance; Metabolic dysfunction; Fatty Liver Disease; Oxidative Stress; Rats | ||
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