STUDY POSSEBLE PROTECTIVE EFFECTS OF NARINGIN AND VITAMINE D3 ON DOXORUBICIN INDUCED CARDIACTOXICITY IN MALE RATS | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Volume 45, Issue 4, October 2025, Pages 565-577 PDF (617.2 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2025.383812.1216 | ||
| Authors | ||
| Eslam Elsaeed Shalaby* 1; Nermin M. Madi1; Fiby Botrose Mina Fawzy2; Elham Nasif3 | ||
| 1The Department of Physiology, Faculty of Medicine, Tanta University, Egypt. | ||
| 2Physiology Department, Faculty of Medicine, Tanta University, Egypt. | ||
| 3Medical Physiology departement, Faculty of Medicine, Tanta University, Tanta, Egypt | ||
| Abstract | ||
| This study examined the protective effects of naringin (NRG) and Vitamin D3 (Vit D3) against cardiac toxicity caused by doxorubicin (DOX) in male albino rats. A total of fifty rats were housed individually and divided into five groups: a control group, a DOX group, and groups treated with NRG, Vit D3, or a combination of both. After a two-week treatment period, researchers collected blood samples to analyze various biochemical markers, including cardiac Troponin I (cTnI), Creatine Kinase (CK), and inflammatory and oxidative stress indicators. The DOX group exhibited significantly elevated levels of cTnI, CKMB, and markers such as TNF-α and Caspase-3, reflecting notable cardiac damage. Additionally, levels of Malondialdehyde (MDA) were increased, while antioxidant enzymes like Superoxide Dismutase (SOD) and Catalase were reduced. In contrast, both NRG and Vit D3 treatments significantly decreased the elevated markers of cardiac injury and oxidative stress. They also improved the activity of antioxidant enzymes, suggesting a protective effect against oxidative damage. Histopathological analysis further demonstrated significant improvements in heart tissue structure in the NRG and Vit D3 groups compared to the DOX group. The findings indicate that the co-administration of NRG and Vit D3 provides enhanced protection against DOX-induced cardiotoxicity, suggesting their potential as therapeutic agents to mitigate heart damage in chemotherapy patients. | ||
| Keywords | ||
| Doxorubicin; Naringin; Vitamin D3; DOX-induced cardiotoxicity | ||
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