Assessment the impact of hybrid dose rates intensity modulated radiation therapy planning technique in patients with head and neck cancer
adel, A., elemary, O., hegazy, H., Abougylah, M., attia, W. (2025). Assessment the impact of hybrid dose rates intensity modulated radiation therapy planning technique in patients with head and neck cancer. EKB Journal Management System, (), -. doi: 10.21608/jcbr.2025.412035.1412
ahmed adel; Omneya elemary; Hanady hegazy; Mohamed Latif Abougylah; wahib attia. "Assessment the impact of hybrid dose rates intensity modulated radiation therapy planning technique in patients with head and neck cancer". EKB Journal Management System, , , 2025, -. doi: 10.21608/jcbr.2025.412035.1412
adel, A., elemary, O., hegazy, H., Abougylah, M., attia, W. (2025). 'Assessment the impact of hybrid dose rates intensity modulated radiation therapy planning technique in patients with head and neck cancer', EKB Journal Management System, (), pp. -. doi: 10.21608/jcbr.2025.412035.1412
adel, A., elemary, O., hegazy, H., Abougylah, M., attia, W. Assessment the impact of hybrid dose rates intensity modulated radiation therapy planning technique in patients with head and neck cancer. EKB Journal Management System, 2025; (): -. doi: 10.21608/jcbr.2025.412035.1412

Assessment the impact of hybrid dose rates intensity modulated radiation therapy planning technique in patients with head and neck cancer

Egyptian Journal of Cancer and Biomedical Research
Articles in Press, Accepted Manuscript, Available Online from 04 October 2025
Document Type: Original Article
DOI: 10.21608/jcbr.2025.412035.1412
Authors
ahmed adel1; Omneya elemary2; Hanady hegazy* 3; Mohamed Latif Abougylah4; wahib attia1
1Medical Physics Department, Faculty of Science, Suez Canal University, Egypt
2Clinical Oncology Specialist, Department of Oncology and Nuclear Medicine, Faculty of medicine, Alexandria University, Egypt
3Alexandria university faculty of medicine
4Department of Oncology and Nuclear Medicine, Faculty of medicine, Alexandria University, Egypt
Abstract
Background: Head and neck cancer incidence is high with radiotherapy representing integral part of treatment with different advanced techniques emerging along with different adverse events profile for each evolving technique. Aim: The objective of the study was to investigate the effects of modifying dose rates in radiotherapy treatment planning and patient-specific quality assurance (PSQA), using the Simultaneous Integrated Boost Intensity Modulated Radiation Therapy (SIB-IMRT) technique.Materials and Methods: Four IMRT plans (600DR 9F IMRT, 1000DR 9F IMRT, 1400DR 9F IMRT, and Hybrid: 3 fields at each dose rate) were developed for 30 patients using SIB-IMRT with the Varian Eclipse system. The plans delivered 69.96 Gy in 33 fractions, and were assessed for targets coverage, organ-at-risks (OARs) sparing, and Patient Specific Quality Assurance (PSQA) using Sun Nuclear's Arc Check.Results: No significant differences were observed in planned target volumes (PTVs) and OARs dosimetric parameters across the four plans. However, PSQA showed significant improvement in the Hybrid plan.Conclusion: Hybrid dose rate SIB IMRT planning may improve PSQA performance while maintaining dosimetric integrity, suggesting a promising approach for head and neck cancer treatment.
Keywords
dose rate; head and neck cancer; radiotherapy planning
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