Assessment the impact of hybrid dose rates intensity modulated radiation therapy planning technique in patients with head and neck cancer | ||
Egyptian Journal of Cancer and Biomedical Research | ||
Articles in Press, Accepted Manuscript, Available Online from 04 October 2025 | ||
Document Type: Original Article | ||
DOI: 10.21608/jcbr.2025.412035.1412 | ||
Authors | ||
ahmed adel1; Omneya elemary2; Hanady hegazy* 3; Mohamed Latif Abougylah4; wahib attia1 | ||
1Medical Physics Department, Faculty of Science, Suez Canal University, Egypt | ||
2Clinical Oncology Specialist, Department of Oncology and Nuclear Medicine, Faculty of medicine, Alexandria University, Egypt | ||
3Alexandria university faculty of medicine | ||
4Department of Oncology and Nuclear Medicine, Faculty of medicine, Alexandria University, Egypt | ||
Abstract | ||
Background: Head and neck cancer incidence is high with radiotherapy representing integral part of treatment with different advanced techniques emerging along with different adverse events profile for each evolving technique. Aim: The objective of the study was to investigate the effects of modifying dose rates in radiotherapy treatment planning and patient-specific quality assurance (PSQA), using the Simultaneous Integrated Boost Intensity Modulated Radiation Therapy (SIB-IMRT) technique.Materials and Methods: Four IMRT plans (600DR 9F IMRT, 1000DR 9F IMRT, 1400DR 9F IMRT, and Hybrid: 3 fields at each dose rate) were developed for 30 patients using SIB-IMRT with the Varian Eclipse system. The plans delivered 69.96 Gy in 33 fractions, and were assessed for targets coverage, organ-at-risks (OARs) sparing, and Patient Specific Quality Assurance (PSQA) using Sun Nuclear's Arc Check.Results: No significant differences were observed in planned target volumes (PTVs) and OARs dosimetric parameters across the four plans. However, PSQA showed significant improvement in the Hybrid plan.Conclusion: Hybrid dose rate SIB IMRT planning may improve PSQA performance while maintaining dosimetric integrity, suggesting a promising approach for head and neck cancer treatment. | ||
Keywords | ||
dose rate; head and neck cancer; radiotherapy planning | ||
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