Prevalence and Antimicrobial Susceptibility of Proteus Species Isolated from wound infections in a Tertiary Care Hospital in Kashmir Valley | ||
| Journal of Medical and Life Science | ||
| Articles in Press, Accepted Manuscript, Available Online from 05 October 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jmals.2025.405331.1061 | ||
| Authors | ||
| Asifa Nazir* 1; Mahnoor Ayoub2 | ||
| 1Department of Microbiology, Government Medical College, Srinagar, Jammu and Kashmir, 190001, India | ||
| 2Government Medical College ,Srinagar | ||
| Abstract | ||
| ABSTRACT Introduction: Proteus species are significant pathogens in wound and soft tissue infections, often exhibiting complex antimicrobial resistance patterns. Understanding their local susceptibility profile is crucial for guiding effective empirical therapy. Objective: To evaluate the antimicrobial susceptibility pattern of Proteus species isolated from pus samples at a tertiary care hospital in Kashmir Valley. Methods: A retrospective study was conducted over 12 months (January 2023- January 2024) at Government Medical College, Srinagar. A total of 10,920 pus samples were received from both OPD and IPD settings of the hospital and cultured after quality evaluation. The recovered isolates were identified by standard microbiological techniques, and antimicrobial susceptibility was assessed by the Kirby-Bauer disc diffusion method following CLSI guidelines. Results: A total of 442 Proteus isolates were recovered from the pus/ wound swabs from the cases of wound infection. Proteus mirabilis was the predominant species (81.4%), followed by Proteus vulgaris (18.6%). Highest sensitivity was observed to piperacillin-tazobactam (88.8%) followed by gentamycin (83.3%) , cefoperazone-sulbactam (72.4%) and imipenem (68%). High resistance rates were observed against ciprofloxacin (66.6%), levofloxacin (67.3%), cefoxitin (73.1%) and amoxicillin-clavulanate (82.7%). Conclusion: Proteus species from pus samples exhibit significant multidrug resistance. Imipenem, piperacillin-tazobactam, and amikacin remain effective options. Routine antimicrobial surveillance and judicious use of antibiotics are necessary to contain resistance. | ||
| Keywords | ||
| Keywords: Proteus species; antimicrobial susceptibility; wound infections | ||
|
Statistics Article View: 13 |
||
