Evaluation of Fresh and Fermented Beet Root as Therapeutic Agents in Experimental Colorectal Cancer in Rats | ||
| مجلة الاقتصاد المنزلي | ||
| Volume 41, Issue 4, December 2025, Pages 143-172 PDF (505.14 K) | ||
| Document Type: المقالة الأصلية | ||
| DOI: 10.21608/jhe.2025.457287 | ||
| Authors | ||
| Aml F. EL-Gazar1; Neveen S. Ismail1; Marwa T. Hassen2; Suhila N. Abdulmajeed1 | ||
| 1Nutrition and Food Sciences Dept., Faculty of Home Economics, Helwan University, Cairo-Egypt | ||
| 2Histology and Histochemistry,Department of Zoology,Women College for Arts, science and Education, Ain Shams University, Cairo-Egypt | ||
| Abstract | ||
| Beet Root (Beta vulgaris L.) Juice having a place to the Chenopodiaceae family, is high in dietary fibers, minerals (manganese, magnesium, potassium, sodium, phosphorus, iron , zinc, copper, boron, silica and selenium), B complex-vitamins. Cancer is a disease differentiated by the improper division and permanence of abnormal cells. When this exists in the colon or rectum, it is known as colorectal cancer. the present study was directed to explore the potential anticancer effect of fresh and fermented beet root juice on rats with colon cancer. Sixty male albino rats were divided into six groups, of eight rats each. Group 1, the negative control group, was fed on the basal diet alone. Groups 2, Positive control group, rats were subcutaneously injected once a week with 35 mg/kg b. wt. of DMH during the experimental period (12 weeks) Groups 3,4 Rats were injected once weekly with 35 mg/kg b. wt. of DMH and were orally received 3 and 5 ml of fresh beet root juice during the experimental period. Groups 5,6 Rats were injected once weekly with 35 mg/kg b. wt. of DMH and were orally received 3 and 5 ml of Fermented beetroot juice (FBRJ) during the experimental period. respectively. while treated groups colon cancer, fed on basal diet and given orally Fresh and Fermented Beet Root had a significant decrease (p<0.05) in the activities of AST, ALT and ALP enzymes, and serum levels of AFP, TNF-α and NF-κ β and CEA and CA, urea, creatinine, and uric acid and MDA, and increased in serum levels of total protein and albumin, activities of antioxidant enzymes (CAT, GSH, and GPx), compared to untreated compared to group (2) rats with induced-colon cancer (positive control). Histopathological examination also showed an obvious improvement in the colon sections of the control colonic Groups 3,4,5,6 Rats were given orally received 3 and 5 ml of fresh and Fermented of beetroot juice (FBRJ) Finally, the existing study illustrated that beetroot juice could improve AST, ALT and ALP enzymes, and serum levels of AFP, TNF-α and NF-κ β and CEA and CA, urea, creatinine, and uric acid and MDA, and serum levels of antioxidant enzymes (CAT, GSH, and GPx). | ||
| Keywords | ||
| Beet Root; DMH; Antioxidant; Colon cancer | ||
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