Predictive value of CA-125 in the outcome of cases of threatened abortion | ||
| International Journal of Medical Arts | ||
| Articles in Press, Accepted Manuscript, Available Online from 06 October 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ijma.2025.404836.2217 | ||
| Authors | ||
| Mohamed Elsaied Mahmoud* 1; Rashed Mohamed Rashed2; Alaa El Arshal2 | ||
| 1Department of Obstetrics and Gynecology, Damietta General Hospital, Ministry of Health, Damietta, Egypt. | ||
| 2Department of Obstetrics and Gynecology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt. | ||
| Abstract | ||
| Background: Threatened abortion is one of the most common obstetric complications in the first trimester and poses a significant risk for pregnancy loss. There is a growing need for reliable, non-invasive biomarkers that can help predict pregnancy outcomes early in gestation. CA-125, a glycoprotein initially identified as a tumor marker, has shown potential prognostic value in early pregnancy complications. Aim: this study aimed to evaluate the predictive value of maternal serum CA-125 levels in determining the outcome of pregnancy in cases of threatened abortion. Patients and methods: This prospective observational study included 100 pregnant women between 7 and 13 weeks of gestation, divided equally into a study group (threatened abortion) and a control group (normal pregnancy). CA-125 levels were measured at presentation, after two weeks, and at 20 weeks of gestation. Participants were followed up to 20 weeks, and outcomes were categorized as either abortion or continued pregnancy. Results: CA-125 levels were significantly higher in the threatened abortion group compared to controls across all measured time points (p < 0.05). Within the threatened abortion group, patients who eventually aborted had significantly higher CA-125 levels than those with ongoing pregnancies. A CA-125 cut-off value >39.3 U/mL at the first visit showed a sensitivity of 82.4%, specificity of 83%, and diagnostic accuracy of 83% (AUC = 0.87) for predicting abortion. Maternal age positively correlated, while gestational age negatively correlated, with CA-125 levels Conclusion: Maternal serum CA-125 measured in the first trimester is a promising, non-invasive biomarker for predicting pregnancy outcome in women with threatened abortion | ||
| Keywords | ||
| CA-125; Threatened abortion; Miscarriage | ||
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