Narrative review on Serum Vitamin D level in Systemic Lupus Erythromatosus | ||
| Egyptian Journal of Medical Microbiology | ||
| Articles in Press, Accepted Manuscript, Available Online from 06 October 2025 | ||
| Document Type: Review articles | ||
| DOI: 10.21608/ejmm.2025.426422.1886 | ||
| Author | ||
| Mervat A.T. Abdel-Aziz* | ||
| Department of Medical Microbiology and Immunology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt; Department of Biomedical Sciences, Microbiology Division, College of Medicine, King Faisal University, Al-Ahsa, Saudi Arabia | ||
| Abstract | ||
| Background: Autoimmune diseases such as Systemic Lupus Erythromatosus (SLE) are longer diagnosed at different age groups and therefore exhibit a major burden on the health services worldwide. The cost of diagnosis and follow up of such cases overwhelmed the community efforts. So, reviewing of possible risk factors is challenging. Vitamin D has classic function on calcium metabolism. It enhances calcium absorption of through regulating numerous intestinal transport proteins. Owing to numerous cells as T lymphocytes, B lymphocytes, dendritic cells and macrophages express vitamin D receptor (VDR) and harbor 1-α-hydroxylase; vitamin D activating enzyme, these immune cells are influenced by serum vitamin D. Moreover, 1-α-hydroxylase enzyme located within these cells isn’t affected by feedback hormonal regulation, and thus, production of active vitamin D (1,25(OH)2D3) is directly dependent on serum concentrations of the substrate level. The present review aims to explore a possible association between concentration of serum vitamin D and SLE focusing on the immunological aspect as promising targets for future therapies or diagnostics modalities. | ||
| Keywords | ||
| SLE; Vitamin D deficiency; microRNAs; IL17; ROS | ||
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