Evaluation of Neutrophil-to-Lymphocyte Ratio with Metabolic, Inflammatory and Oxidative Stress Markers in Hypothyroid Dogs with Autoimmune Thyroiditis | ||
| Egyptian Journal of Veterinary Sciences | ||
| Articles in Press, Corrected Proof, Available Online from 06 October 2025 PDF (650.79 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejvs.2025.417655.3080 | ||
| Authors | ||
| Gehad Elsaid Elgalfy* 1; Mahmoud A Helal2; Heba Mohamed Elkhaiat3; Mohamed M Ghanem4 | ||
| 1animal medicine department, faculty of veterinary medicine, benha university | ||
| 2faculty of veterinarymedicine- moshtohor- toukh - kalioubia | ||
| 3Animal Medicine Department Faculty of vetrinary medicine, Benha university | ||
| 4benha university | ||
| Abstract | ||
| Lymphocytic thyroiditis is an autoimmune-mediated destruction of thyroid tissue and considered as the most prevalent cause of canine hypothyroidism. This study aimed to evaluate the neutrophil-to-lymphocyte ratio (NLR) as a marker of inflammation in hypothyroid dogs with lymphocytic thyroiditis. Additionally, aimed to investigate the role of thyroid autoimmunity and oxidative stress in the pathophysiology of thyroid dysfunction and disease progression. Hypothyroidism was diagnosed in 51 dogs, among which 15 dogs were diagnosed with lymphocytic thyroiditis based on the presence of thyroglobulin autoantibodies (TgAA) in their serum, these 15 dogs were included in this study. Ten additional healthy dogs were included as the control group. The affected dogs in the present study showed a variety of clinical signs including dermatological and metabolic abnormalities along with significant alterations in the levels of total thyroxin (TT4), free thyroxin (FT4), and thyroid stimulating hormones (TSH). A statistically significant elevation of NLR was detected in dogs with lymphocytic thyroiditis when compared to healthy dogs. Serum biochemical analysis demonstrated significant changes in liver function, total protein, lipid profile and fructosamine. Oxidative stress biomarkers showed a significant decrease in catalase and superoxide dismutase with a statistically significant increase in Malondialdehyde level. The present study concluded that the combination between NLR and TgAA measurements offers a more comprehensive evaluation of autoimmune thyroiditis by reflecting both specific immune activity and systemic inflammation. Oxidative stress, closely linked to lymphocytic thyroiditis, acts as both a cause and effect of thyroid dysfunction, suggesting potential benefits of antioxidant therapy in some cases. | ||
| Keywords | ||
| Dogs; Hypothyroidism; lymphocytic thyroiditis; NLR; Oxidative stress; TgAA | ||
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