Comparative Efficacy of Autologous Platelet-Rich Plasma and Zinc Oxide Nanoparticles in Accelerating Cutaneous Wound Healing: A Randomized Controlled Study in Rabbits | ||
| Egyptian Journal of Veterinary Sciences | ||
| Articles in Press, Corrected Proof, Available Online from 06 October 2025 PDF (756.12 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejvs.2025.418691.3089 | ||
| Authors | ||
| Abdulaziz Faisal Alhussain1; Saleh Abdmoeneem Alsayed2; Mohamed A. Marzok3; Abdelrahman Hereba4; Mohamed W. El-Sherif* 5; Mohamed Abdelkawi6 | ||
| 1Department of Clinical Studies, College of Veterinary Medicine, King Faisal University, Saudi Arabia. | ||
| 2Department of Clinical Studies, College of Veterinary Medicine, King Faisal University, Al Ahsaa 31982, Saudia Arabia. | ||
| 3Department of Clinical Sciences, Faculty of Veterinary Medicine, King Faisal University, Al-Ahsa, KSA. | ||
| 4Department of Microbiology, College of Veterinary Medicine, King Faisal University, Al Ahsaa 31982, Saudia Arabia. | ||
| 5Department of Surgery, Faculty of Veterinary Medicine, New Valley University, Al kharga, New Valley 27511, Egypt. | ||
| 6Department of Surgery, Faculty of Veterinary Medicine, New Valley University, Al Kharga, New Valley 27511, Egypt. | ||
| Abstract | ||
| Advanced wound therapies are needed to enhance healing beyond standard care. We compared autologous platelet-rich plasma (PRP) with zinc oxide nanoparticles (ZnO NPs) for full-thickness cutaneous wound repair in rabbits. Thirty-six male New Zealand White rabbits (n = 12/group) received topical PRP, ZnO NPs, or saline on two standardized dorsal wounds (20 mm in diameter). Treatments were applied once daily for 5 days, then on alternate days until closure or Day 21. Both treatments accelerated healing versus control. On Day 15, mean closure was 95.6% (PRP), 89.7% (ZnO NPs), and 76.4% (control; all P < 0.001 vs control). Time to ≥99% closure was 17.3 ± 2.1 (PRP), 19.8 ± 2.4 (ZnO NPs), and 23.7 ± 3.2 days (control); PRP was faster than ZnO NPs (P = 0.007). PRP yielded higher angiogenesis and VEGF expression at Day 14 (198.5 ± 24.8 vs 168.9 ± 22.1; P = 0.008) with favorable modulation of TNF-α. Both modalities were safe; PRP showed greater overall efficacy. | ||
| Keywords | ||
| Platelet-Rich Plasma; Zinc Oxide Nanoparticles; Wound Healing; Angiogenesis; Growth Factors | ||
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