The Interaction of Activated Vitamin D3 In Rats Exposed to Experimentally Induced Type I or II Diabetes Mellitus | ||
| Egyptian Journal of Veterinary Sciences | ||
| Articles in Press, Corrected Proof, Available Online from 06 October 2025 PDF (835.27 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejvs.2025.407126.2990 | ||
| Authors | ||
| Menna Sayed1; El-Said El-Sherbini1; Zeinab Dwidar2; Mohamed El-Adl* 1 | ||
| 1Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Mansoura University, Egypt | ||
| 2Department of Pathology, Faculty of Veterinary Medicine, Mansoura University, Egypt | ||
| Abstract | ||
| The current study was conducted to evaluate the interaction of activated vitamin D3 with rats exposed to type I or type II diabetes mellitus Rats’ models of both type I and II diabetes mellitus were conducted using a single dose of streptozotocin (60mg/ kg.b.wt) and 40% dietary fructose, respectively. After the induction of both types of diabetes mellitus, rats were supplemented with activated vitamin D3 (1µg/ kg . b.wt). At the end of the experiment, plasma blood glucose level, serum blood insulin level, lipid profile, antioxidant status markers (MDA, GSH, and CAT), and hepatic adiponectin, galectin, and VDR gene expression analysis were estimated. Serum blood insulin, Plasma blood glucose, lipid profile (LDL, HDL, cholesterol, TAG ), and redox state markers, as well as hepatic gene expression of adiponectin, galectin, and vitamin D receptor, showed significant deteriorations in the type I diabetic group and type II diabetic group which were improved significantly in the treated groups It can be concluded that supplementation of activated vitamin D3 can improve glycemic status, serum lipid profile and antioxidant status in rats exposed to type I or type II diabetes mellitus. | ||
| Keywords | ||
| Diabetes mellitus; vitamin D; Adiponectin; Galectin-3; VDR; STZ | ||
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