The Role of Advanced New MRI Parameters in Cardiomyopathies
El- Mozy, W., Said, A., Shabaan, E., Abd El- Mageed, N. (2025). The Role of Advanced New MRI Parameters in Cardiomyopathies. EKB Journal Management System, 6(3), 225-248. doi: 10.21608/ejmr.2024.236777.1461
Wesam Emam Aly El- Mozy; Ahmed Hesham Said; Esraa Abd El- Latief Shabaan; Naglaa Ezzat Abd El- Mageed. "The Role of Advanced New MRI Parameters in Cardiomyopathies". EKB Journal Management System, 6, 3, 2025, 225-248. doi: 10.21608/ejmr.2024.236777.1461
El- Mozy, W., Said, A., Shabaan, E., Abd El- Mageed, N. (2025). 'The Role of Advanced New MRI Parameters in Cardiomyopathies', EKB Journal Management System, 6(3), pp. 225-248. doi: 10.21608/ejmr.2024.236777.1461
El- Mozy, W., Said, A., Shabaan, E., Abd El- Mageed, N. The Role of Advanced New MRI Parameters in Cardiomyopathies. EKB Journal Management System, 2025; 6(3): 225-248. doi: 10.21608/ejmr.2024.236777.1461

The Role of Advanced New MRI Parameters in Cardiomyopathies

Egyptian Journal of Medical Research
Volume 6, Issue 3, July 2025, Pages 225-248    PDF (799.7 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2024.236777.1461
Authors
Wesam Emam Aly El- Mozy1; Ahmed Hesham Said2; Esraa Abd El- Latief Shabaan* 3; Naglaa Ezzat Abd El- Mageed2
1Radiodiagnosis, Cairo University, Egypt
2Radiodiagnosis, Beni-Suef University, Egypt
3M.B.B.Ch., Diploma degree, Beni-Suef University, Egypt
Abstract
Background: Cardiac magnetic resonance imaging (CMR) has made major inroads in the new millennium in diagnosing and assessing the prognosis for patients with cardiomyopathies. Aim: The study aimed to demonstrate MRI characteristics of different types of cardiomyopathies by using MRI parameters of myocardial tissue characterization (T1 mapping & ECV) and strain analysis. Methods: This was a retrospective study conducted on a total of 130 cases with free distribution from men, women and children at Aswan Heart Center from January 2021 to January 2023.  Echocardiography confirmed the diagnosis of cardiomyopathy in one hundred of them. We grouped them as 30 patients in the DCM group, 27 patients in the ICM group, 31 patients in the HCM group, and 12 patients from other types (RCM, ARVD, and LVNC). The other thirty people represented controls (A part from health volunteer program at Aswan Heart Center). Results: Statistically significant T1 mapping values at basal inferior, basal inferolateral and mid inferoseptal segments in the ICM group and basal inferior segments in the DCM group. Statistically significant global Circumferential, Radial and Longitudinal strain analysis in the ICM, DCM and Others groups, and only global longitudinal strain analysis in the HCM group.
Keywords
Cardiac magnetic resonance imaging; Cardiomyopathies; T1 mapping; Strain analysis; Feature tracking
References

  1. Kramer M, Jörg B, Scott D, Raymond J, Eike N, Society for Cardiovascular Magnetic Resonance Board of Trustees Task Force on Standardized Protocols. Standardized cardiovascular magnetic resonance (CMR) protocols 2013 update. Journal of Cardiovascular Magnetic Resonance. 2013; 15(1): 91.
  2. O’Donnell H, Suhny A, Vithaya C, Kibar Y, Ronan P, Ramon M, et al. Cardiac MR imaging of nonischemic cardiomyopathies: imaging protocols and spectra of appearances. 2012; 262(2): 403-422.
  3. Jan B, Steven D, Andrew M. Clinical Cardiac MRI. Springer Science and Business Media. 2012.
  4. Puntmann VO, Voigt T, Chen Z, Mayr M, Karim R, Rhode K, Pastor A, Carr-White G, Razavi R, Schaeffter T, Nagel E. Native T1 Mapping in Differentiation of Normal Myocardium From Diffuse Disease in Hypertrophic and Dilated Cardiomyopathy. JACC Cardiovasc Imaging. 2013;6:475–84.
  5. Dass S, Suttie JJ, Piechnik SK, Ferreira VM, Holloway CJ, Banerjee R, Mahmod M, Cochlin L, Karamitsos TD, Robson MD, Watkins H, Neubauer S. Myocardial tissue characterization using magnetic resonance non-contrast t1 mapping in hypertrophic and dilated cardiomyopathy. Circ Cardiovasc Imaging. 2012;5:726–33.
  6. Sado DM, Flett AS, Banypersad SM, White SK, Maestrini V, Quarta G, Lachmann RH, Murphy E, Mehta A, Hughes DA, McKenna WJ, Taylor AM, Hausenloy DJ, Hawkins PN, Elliott PM, Moon JC. Cardiovascular magnetic resonance measurement of myocardial extracellular volume in health and disease. Heart. 2012;98:1436–41.
  7. Swoboda PP, McDiarmid AK, Erhayiem B, Broadbent DA, Dobson LE, Garg P, Ferguson C, Page SP, Greenwood JP, Plein S. Assessing Myocardial Extracellular Volume by T1 Mapping to Distinguish Hypertrophic Cardiomyopathy From Athlete’s Heart. J Am Coll Cardiol. 2016;67:2189–90.
  8. Todiere G, Aquaro GD, Piaggi P, Formisano F, Barison A, Masci PG, Strata E, Bacigalupo L, Marzilli M, Pingitore A, Lombardi M. Progression of myocardial fibrosis assessed with cardiac magnetic resonance in hypertrophic cardiomyopathy. J Am Coll Cardiol. 2012;60:922–9.
  9. aus dem Siepen F, Buss SJ, Messroghli D, Andre F, Lossnitzer D, Seitz S, Keller M, Schnabel PA, Giannitsis E, Korosoglou G, Katus HA, Steen H. T1 mapping in dilated cardiomyopathy with cardiac magnetic resonance: quantification of diffuse myocardial fibrosis and comparison with endomyocardial biopsy. Eur Heart J Cardiovasc Imaging. 2015;16:210–6.
  10. Scatteia, A, Baritussio, A, & Bucciarelli-Ducci, C. Strain imaging using cardiac magnetic resonance. Heart Failure Reviews. 2017; 22(4): 465–476.
  11. Muser, D, Castro, S. A, Santangeli, P, & Nucifora G. Clinical applications of feature-tracking cardiac magnetic resonance imaging. World Journal of Cardiology. 2018; 10(11): 210–221.
  12. Ulrike B, Timothy L, Christian S, Stephen S, Sergio U, Reza R, et al. Interleaved T1 and T2 Relaxation Time Mapping for Cardiac Applications. Journal of Magnetic Resonance Imaging. 2009; 29:480 –487.
  13. Stefan K, Vanessa M, Erica D, Lowri E, Andreas G, Stefan N, et al. Shortened Modified Look-Locker Inversion recovery (ShMOLLI) for clinical myocardial T1-mapping at 1.5 and 3 T within a 9-heartbeat breath hold. Journal of Cardiovascular Magnetic Resonance. 2010; 12(1): 69.
  14. Leah I, Heinz P, Arintaya P, Joshi C, Pelin A, Sandeep N, et al. Evaluation of diffuse myocardial fibrosis in heart failure with cardiac magnetic resonance contrast-enhanced T1 mapping. Journal of the American College of Cardiology. 2008; 52(19): 1574-80.
  15. Martin U, Abiola J, Li-Yueh H, Peter K, Andreas G, Anthony H, et al. Extracellular volume imaging by magnetic resonance imaging provides insights into overt and sub-clinical myocardial pathology. European Heart Journal. 2012; 33(10): 1268-1278.
  16. Nathan M, Chia Y, Pierre C, David B, João A C. Assessment of myocardial fibrosis with cardiovascular magnetic resonance. Journal of the American College of Cardiology. 2011; 57(8): 891-903.
  17. Barallobre-Barreiro J., Didangelos A., Schoendube F.A., Drozdoy I., Yin X. Proteomics Analysis of Cardiac Extracellular Matrix Remodeling in a Porcine Model of Ischemia-Reperfusion Injury. Circulation. 2012; 125(6): 789-802
  18. Polacin M, Karolyi M, Eberhard M, Gotschy A, Baessler B, Alkadhi H. Segmental strain analysis for the detection of chronic ischemic scars in non ‑ contrast cardiac MRI cine images. Scientific Reports. 2021; 1–11.
  19. Scatteia, A., Baritussio, A., & Bucciarelli-Ducci, C. Strain imaging using cardiac magnetic resonance. Heart Failure Reviews. 2017; 22(4): 465–476.
Statistics
Article View: 41
PDF Download: 26