Histopathological Changes of Minimal Associated Pathological Lesions of Vocal Folds: Comparative Study between Smokers versus Non-smokers
Anter, A., Youssef, R., ِAzab, S., Mahmoud, E., Aboud, M., Saleh, S. (2025). Histopathological Changes of Minimal Associated Pathological Lesions of Vocal Folds: Comparative Study between Smokers versus Non-smokers. EKB Journal Management System, 6(3), 249-265. doi: 10.21608/ejmr.2025.328765.1718
Amr Abdelsalam Anter; Rabie Sayed Youssef; Safinaz Nagib ِAzab; Ebtehal Mohamed Mostafa Mahmoud; Manar Mahmoud Mohamed Aboud; Shaimaa Ahmed Saleh. "Histopathological Changes of Minimal Associated Pathological Lesions of Vocal Folds: Comparative Study between Smokers versus Non-smokers". EKB Journal Management System, 6, 3, 2025, 249-265. doi: 10.21608/ejmr.2025.328765.1718
Anter, A., Youssef, R., ِAzab, S., Mahmoud, E., Aboud, M., Saleh, S. (2025). 'Histopathological Changes of Minimal Associated Pathological Lesions of Vocal Folds: Comparative Study between Smokers versus Non-smokers', EKB Journal Management System, 6(3), pp. 249-265. doi: 10.21608/ejmr.2025.328765.1718
Anter, A., Youssef, R., ِAzab, S., Mahmoud, E., Aboud, M., Saleh, S. Histopathological Changes of Minimal Associated Pathological Lesions of Vocal Folds: Comparative Study between Smokers versus Non-smokers. EKB Journal Management System, 2025; 6(3): 249-265. doi: 10.21608/ejmr.2025.328765.1718

Histopathological Changes of Minimal Associated Pathological Lesions of Vocal Folds: Comparative Study between Smokers versus Non-smokers

Egyptian Journal of Medical Research
Volume 6, Issue 3, July 2025, Pages 249-265    PDF (679.23 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2025.328765.1718
Authors
Amr Abdelsalam Anter1; Rabie Sayed Youssef* 2; Safinaz Nagib ِAzab3; Ebtehal Mohamed Mostafa Mahmoud4; Manar Mahmoud Mohamed Aboud5; Shaimaa Ahmed Saleh6
1Lecturer of Phoniatrics, ENT department Faculty of Medicine – Beni-Suef University, Egypt
2Assistant Professor of Otorhinolaryngology, Faculty of Medicine, Beni-Suef University, Egypt.
3Professor of Phoniatrics, ENT department, Faculty of medicine, Beni-suef University
4Lecturer of pathology Faculty of medicine - Beni-Suef University.
5M.B., B. Ch Faculty of medicine – Beni-suef university
6Lecturer of Phoniatrics, ENT department Faculty of Medicine – Beni-Suef University
Abstract
Objectives: Investigate the impact of cigarette smoking on the histopathology of resected minimal associated pathological lesions and compare it with the histopathology of the lesions of non-smoker patients for a better understanding of these changes, follow-up and proper management. Methods: There are two groups of 60 patients, (group A): 30 smokers and (group B): 30 non-smokers, they were selected from the outpatient clinic, Phoniatrics unit of Beni-Suef University Hospital both males and females, and both groups underwent micro-laryngeal surgery then histopathological examination for the resected lesions. Results: showed that smokers had a higher incidence of keratinization and dysplasia, as well as basement membrane changes in their lesions compared to non-smokers. Additionally, smokers had more hyaline degeneration. These findings suggest that cigarette smoke can have harmful effects on the epithelium and lamina propria of minimal associated pathological lesions. Conclusion: Cigarette smoking causes histologic alterations in the minimal associated pathological lesions, dysplasia, keratinization, and basement membrane changes, which were significantly higher in the smokers group.
Keywords
Minimal associated pathological lesions; Smoking; Histopathological changes; Dysplasia
References

  1. El-Halaby H, El-Begermy MM, Hakim MZ. Use of Co2 Laser versus conventional microlaryngeal surgery in treatment of vocal fold benign lesions. QJM: An International Journal of Medicine. 2021;114(Supplement_1). doi: https://doi.org/10.1093/qjmed/hcab094.012
  2. Saha DrPP, Jana DrS. A Clinicopathological Study of Benign Lesions of the Vocal Fold. IOSR Journal of Dental and Medical Sciences. 2017;16(02):09-12. doi: https://doi.org/10.9790/0853-1602010912.
  3. Thakur M, Guttikonda V, Rao. Saudi Journal of Pathology and Microbiology Tumour Invasion and Metastasis: A review. doi: https://doi.org/10.21276/sjpm.2016.1.2.7.
  4. Levendoski EE, Leydon C, Thibeault SL. Vocal Fold Epithelial Barrier in Health and Injury A Research Review. Journal of speech, language, and hearing research: JSLHR. 2014;57(5):1679-1691. doi: https://doi.org/10.1044/2014_JSLHR-S-13-0283
  5. Trupthi M, Paul RR, Mukhopadhyay S, Thomas M, Anbuselvi RR. Effect of Smoking on Vocal Fold Polyp: A Comparative Histopathological Study. An International Journal of Otorhinolaryngology Clinics. 2022;13(3):95-100. doi: https://doi.org/10.5005/jp-journals-10003-1387.
  6. Tobacco smoking in Egypt: a scoping literature review of its epidemiology and control measures. World Health Organization - Regional Office for the Eastern Mediterranean. https://www.emro.who.int/emhj-volume-24-2018/volume-24-issue-2/tobacco-smoking-in-egypt-a-scoping-literature-review-of-its-epidemiology-and-control-measures.html#:~:text=As%20indicated%20in%20Table%201c
  7. Núñez-Regueiro M. Yaşlı Kadınlarda Üreme Sağlığı. DergiPark (Istanbul University). 2020;1(1). doi: https://doi.org/10.1016/j
  8. Oliveira P, Ribeiro VV, Constantini AC, Cavalcante ME de OB, Sousa M dos S, da Silva K. Prevalence of Work-Related Voice Disorders in Voice Professionals: Systematic Review and Meta-Analysis. Journal of Voice. Published online August 2022. doi: https://doi.org/10.1016/j.jvoice.2022.07.030.
  9. Dworkin JP. Laryngitis: Types, Causes, and Treatments. Otolaryngologic Clinics of North America. 2008;41(2):419-436. doi: https://doi.org/10.1016/j.otc.2007.11.011.
  10. Şanlı A. Relationship between smoking and otorhinolaryngological symptoms. The Turkish Journal of Ear Nose and Throat. 2016;26(1):28-33. doi: https://doi.org/10.5606/kbbihtisas.2016.87059.
  11. Ness-Jensen E, Lagergren J. Tobacco smoking, alcohol consumption and gastro-oesophageal reflux disease. Best Practice & Research Clinical Gastroenterology. 2017;31(5):501-508. doi: https://doi.org/10.1016/j.bpg.2017.09.004
  12. Marcotullio D, Magliulo G, Pezone T. Reinke’s edema and risk factors: Clinical and histopathologic aspects. American Journal of Otolaryngology. 2002;23(2):81-84. doi: https://doi.org/10.1053/ajot.2002.30961.
  13. Butler JE, Hammond TH, Gray SD. Gender-related differences of hyaluronic acid distribution in the human vocal fold. Laryngoscope. 2001 May;111(5):907-11. doi: 10.1097/00005537-200105000-00029. PMID: 11359176.
  14. Hirano, S.; Inufusa, H.; You, F. The Effect of Oxidative Stress on the Human Voice. Int. J. Mol. Sci. 2024, 25, 2604. https://doi.org/10.3390/ijms25052604
  15. Montgomery J, White A. A decade of laryngeal dysplasia in Paisley, Scotland. European Archives of Oto-Rhino-Laryngology. 2011;269(3):947-951. doi: https://doi.org/10.1007/s00405-011-1684-x.
  16. Josilene Luciene Duarte, Augusto F, Danielle Santi Ceolin, Tania Mary Cestari, Francisco. Effects of passive smoke inhalation on the vocal cords of rats. Brazilian Journal of Otorhinolaryngology. 2006;72(2):210-216. doi: https://doi.org/10.1016/s1808-8694(15)30057-4.
  17. Işik ACU, Kalender Y, Yardimci S, Ergün A. Environmental tobacco smoke in rats. The Journal of Otolaryngology. 2004;33(6):382-386. Accessed July 26, 2024. https://pubmed.ncbi.nlm.nih.gov/15971655.
  18. Park JC, Altman KW, Prasad VMN, Broadhurst M, Akst LM. Laryngeal Leukoplakia: State of the Art Review. Otolaryngology–Head and Neck Surgery. Published online November 10, 2020:019459982096591. doi: https://doi.org/10.1177/0194599820965910.
  19. Effat KG, Milad M. A comparative histopathological study of vocal fold polyps in smokers versus non-smokers. The Journal of Laryngology & Otology. 2015;129(5):484-488. doi: https://doi.org/10.1017/s002221511500064x.
 

 

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