Histopathological Changes of Minimal Associated Pathological Lesions of Vocal Folds: Comparative Study between Smokers versus Non-smokers
Anter, A., Youssef, R., ِAzab, S., Mahmoud, E., Aboud, M., Saleh, S. (2025). Histopathological Changes of Minimal Associated Pathological Lesions of Vocal Folds: Comparative Study between Smokers versus Non-smokers. EKB Journal Management System, 6(3), 249-265. doi: 10.21608/ejmr.2025.328765.1718
Amr Abdelsalam Anter; Rabie Sayed Youssef; Safinaz Nagib ِAzab; Ebtehal Mohamed Mostafa Mahmoud; Manar Mahmoud Mohamed Aboud; Shaimaa Ahmed Saleh. "Histopathological Changes of Minimal Associated Pathological Lesions of Vocal Folds: Comparative Study between Smokers versus Non-smokers". EKB Journal Management System, 6, 3, 2025, 249-265. doi: 10.21608/ejmr.2025.328765.1718
Anter, A., Youssef, R., ِAzab, S., Mahmoud, E., Aboud, M., Saleh, S. (2025). 'Histopathological Changes of Minimal Associated Pathological Lesions of Vocal Folds: Comparative Study between Smokers versus Non-smokers', EKB Journal Management System, 6(3), pp. 249-265. doi: 10.21608/ejmr.2025.328765.1718
Anter, A., Youssef, R., ِAzab, S., Mahmoud, E., Aboud, M., Saleh, S. Histopathological Changes of Minimal Associated Pathological Lesions of Vocal Folds: Comparative Study between Smokers versus Non-smokers. EKB Journal Management System, 2025; 6(3): 249-265. doi: 10.21608/ejmr.2025.328765.1718

Histopathological Changes of Minimal Associated Pathological Lesions of Vocal Folds: Comparative Study between Smokers versus Non-smokers

Egyptian Journal of Medical Research
Volume 6, Issue 3, July 2025, Pages 249-265    PDF (679.23 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2025.328765.1718
Authors
Amr Abdelsalam Anter1; Rabie Sayed Youssef* 2; Safinaz Nagib ِAzab3; Ebtehal Mohamed Mostafa Mahmoud4; Manar Mahmoud Mohamed Aboud5; Shaimaa Ahmed Saleh6
1Lecturer of Phoniatrics, ENT department Faculty of Medicine – Beni-Suef University, Egypt
2Assistant Professor of Otorhinolaryngology, Faculty of Medicine, Beni-Suef University, Egypt.
3Professor of Phoniatrics, ENT department, Faculty of medicine, Beni-suef University
4Lecturer of pathology Faculty of medicine - Beni-Suef University.
5M.B., B. Ch Faculty of medicine – Beni-suef university
6Lecturer of Phoniatrics, ENT department Faculty of Medicine – Beni-Suef University
Abstract
Objectives: Investigate the impact of cigarette smoking on the histopathology of resected minimal associated pathological lesions and compare it with the histopathology of the lesions of non-smoker patients for a better understanding of these changes, follow-up and proper management. Methods: There are two groups of 60 patients, (group A): 30 smokers and (group B): 30 non-smokers, they were selected from the outpatient clinic, Phoniatrics unit of Beni-Suef University Hospital both males and females, and both groups underwent micro-laryngeal surgery then histopathological examination for the resected lesions. Results: showed that smokers had a higher incidence of keratinization and dysplasia, as well as basement membrane changes in their lesions compared to non-smokers. Additionally, smokers had more hyaline degeneration. These findings suggest that cigarette smoke can have harmful effects on the epithelium and lamina propria of minimal associated pathological lesions. Conclusion: Cigarette smoking causes histologic alterations in the minimal associated pathological lesions, dysplasia, keratinization, and basement membrane changes, which were significantly higher in the smokers group.
Keywords
Minimal associated pathological lesions; Smoking; Histopathological changes; Dysplasia
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