Effect of oral antihypertensive drugs on the fetal and Uteroplacental blood flow | ||
| The Egyptian Journal of Fertility and Sterility | ||
| Volume 29, Issue 5 - Serial Number 11106352, September 2025, Pages 32-40 PDF (244.69 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/egyfs.2025.457885 | ||
| Authors | ||
| Ahmed Mohamed Nofal* 1; D. I. Morsi1; Y.A. Alghalban2; S.A. Hassanein3 | ||
| 1Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Egypt | ||
| 2Department of Public Health and Community Medicine, Faculty of Medicine, Menoufia University, Egypt | ||
| 3Department of Radiology, Faculty of Medicine, Menoufia University, Egypt | ||
| Abstract | ||
| Background: PIH Complications may be related to pla-cental insufficiency can be detected through uterine and umbilical arteries Doppler. Objective: Was postulated to detect the impacts of α-Methyldopa and Labetalol on Doppler flow in fetal um-bilical arteries and maternal Uterine arteries in females with gestational hypertension. Patients and methods: 176 pregnant women with ges-tational hypertension who required oral antihypertensive drugs. underwent thorough history taking, physical exam-ination and lab investigations. Obstetric ultrasound with Doppler ultrasound assessment of S/D ratio, Resistive index (RI) and Pulsatility index (PI) in both uterine and umbilical arteries was done as baseline before and after treatment. Results: mean Uterine arteries RI, systole /diastole ratio showed a significant decrease while PI didn’t show a sig-nificant difference. Umbilical artery RI showed a signifi-cant decrease, systole /diastole ratio and PI didn’t show asignificant difference before and after treat-ment with Labetalol Mean Uterine arteries RI, systole /diastole ratio showed a signifi-cant decrease while PI didn’t show a signifi-cant difference. Umbilical artery RI showed a significant decrease, systole /diastole ratio and PI didn’t show a significant difference before and after treatment with α- methyl dopa. Conclusion: Doppler studies of uterine and umbilical arteries revealed a significant de-crease in RI and S/D ratio in uterine arteries blood flow with labetalol and methyl dopa therapy and a significant decrease in RI in umbilical artery blood flow after Labetalol and methyl Dopa treatment, these changes may be related to the vasodilatory effect of the antihypertensive drugs. | ||
| Keywords | ||
| Gestational hypertension; dop-pler; Labetalol; α- methyl dopa | ||
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