AMELIORATIVE EFFECT OF COENZYME Q 10 ON TITANIUM DIOXIDE NANOPARTICLES INDUCED HEPATOTOXICITY IN RATS | ||
| Assiut Veterinary Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 08 October 2025 PDF (2.23 M) | ||
| Document Type: Research article | ||
| DOI: 10.21608/avmj.2025.380543.1684 | ||
| Authors | ||
| GHADA M. ABDALLAH* ; MOKHTAR M. TAHA; KHALED M.A. HASSANEIN | ||
| Department of Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut 71526, Egypt | ||
| Abstract | ||
| This study aimed to explore the ameliorative effect of Coenzyme Q10 (CoQ10) on Titanium dioxide nanoparticles (TiO2 NPs)-induced hepatotoxicity. Sixty adult male albino rats were divided into four groups, with 15 rats in each group. Group (A) was administered only a vehicle (1% Tween 80). Group (B) was administered TiO2NPs daily by gastric tube (100 mg/kg.bwt) for three months. Group (C) was administered TiO2NPs (100 mg/kg.bwt) and simultaneously administered CoQ10 (10 mg/kg.bw) daily by gastric tube for the same period. Group (D) was administered CoQ10 only. At the end of the experiment, serum samples and tissue samples from the liver were collected for the detection of liver enzyme markers and histopathological examination, respectively. The TiO2 NPs-intoxicated 2NPs-intoxicated group showed elevation in the liver enzyme markers aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Also, the histopathological results revealed vascular and parenchymatous changes. The vascular changes were in the form of congestion and thrombosis of the blood vessels. The parenchymatous changes were vacuolar degeneration of hepatocytes, necrosis, apoptosis, hyperplasia of the bile duct epithelium and hepatic fibrosis. TiO2NPs and CoQ10 treated group revealed a decrease in the levels of AST and ALT and an improvement of the histological architecture of the liver tissue. It was concluded that chronic toxicity of TiO2NPs induced histopathological alterations in the liver. The administration of CoQ10 ameliorated the liver damage induced by TiO2NPs via its antioxidative and anti-inflammatory properties. | ||
| Keywords | ||
| TiO2NPs; CoQ10; AST; ALT; histopathology | ||
|
Statistics Article View: 3 PDF Download: 1 |
||
