Comprehensive Clinical Overview of Gallstones (Cholelithiasis): Epidemiology, Pathophysiology, Diagnosis, and Evidence-Based Management for Healthcare Professionals. | ||
| Egyptian Journal of Chemistry | ||
| Volume 68, Issue 13, December 2025, Pages 1313-1324 PDF (1.58 M) | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/ejchem.2025.413213.12170 | ||
| Authors | ||
| Manar Obaid Alanazi* ; Majed Battah Alshammari; Turki Saleh Alduhaim; Fahad Mohamed Alanazi; Jaber Ali Hassan Alshehri; Munirah Fayez Alharbi; Noran Mohammed Alghamdi; Nadyah Khalaf Safi Alanazi; Dalal Khalaf Safi Alanazi; Ghadeer Hemaidan Altalhi; Alanoud Salman Alshalawi | ||
| Ministry of National Guard, Saudi Arabia | ||
| Abstract | ||
| Background: Gallstones (cholelithiasis) are a prevalent digestive disorder affecting millions worldwide, with a higher incidence in women and older adults. While often asymptomatic, a significant minority develop symptoms or complications ranging from biliary colic to life-threatening conditions like cholecystitis, cholangitis, and pancreatitis. Aim: This article provides a comprehensive clinical overview of gallstones for healthcare professionals, covering epidemiology, pathophysiology, diagnostic approaches, and evidence-based management strategies. Methods: The review synthesizes current medical knowledge on gallstone formation, which involves an imbalance in bile composition (supersaturation of cholesterol or bilirubin), gallbladder stasis, and genetic, metabolic, and microbial factors. Diagnosis relies heavily on clinical history, physical examination, and ultrasonography as the primary imaging modality, with additional roles for CT, MRI/MRCP, and HIDA scans. Results: Management is dictated by symptom presence and complication severity. Asymptomatic stones often require no intervention. For symptomatic or complicated disease, laparoscopic cholecystectomy is the definitive treatment. Endoscopic retrograde cholangiopancreatography (ERCP) is crucial for managing common bile duct stones, while conservative and medical therapies have limited, niche roles. Conclusion: Gallstone disease represents a significant clinical and economic burden. Accurate diagnosis and risk stratification are essential. Surgical removal of the gallbladder remains the cornerstone of treatment for symptomatic patients, providing durable symptom resolution and preventing complications | ||
| Keywords | ||
| Gallstones; Cholelithiasis; Epidemiology; Pathophysiology; Ultrasonography; Cholecystectomy; ERCP | ||
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