Gut Microbiota and its Implication in Disease: A Mini-Review | ||
| Records of Pharmaceutical and Biomedical Sciences | ||
| Volume 9, Issue 2, March 2025, Pages 134-142 PDF (782.07 K) | ||
| Document Type: Mini-reviews | ||
| DOI: 10.21608/rpbs.2025.410123.1393 | ||
| Author | ||
| Kareem Talaat Ismail* | ||
| Microbiology & Immunology, Faculty of Pharmacy, MSA University | ||
| Abstract | ||
| The human flora has an indispensable function in maintaining human health and has also recently been implicated in the etiology of many diseases. This mini-review highlights those associations with respect to gastrointestinal, liver, metabolic, cardiovascular, immune, and neuropsychiatric diseases. Dysbiosis, or microbial imbalance, has been linked to irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), non-alcoholic fatty liver disease (NAFLD), obesity, diabetes, cardiovascular disease (CVD), asthma, and neurological disorders. The link could be brought about by altered fermentation processes, increased immune activation, and/or compromised gut barrier functions. Apart from those established through international studies, there is a lack of evidence from Egypt. Unique factors of a given region, including food habits and environmental exposures, ought to contribute to shaping distinct microbial fingerprints. Therefore, a concerted push for future local studies is warranted to delineate the role of gut microbiota in health and disease in the Egyptian population and in similarly under-represented settings. | ||
| Keywords | ||
| Gut microbiota; Dysbiosis; Metabolic disorders; Inflammatory bowel disease; Gut-brain axis | ||
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