Clinical Characteristics and Outcomes of COVID-19 in Chronic Kidney Disease Patients on Hemodialysis | ||
| Journal of Medical and Life Science | ||
| Articles in Press, Accepted Manuscript, Available Online from 10 October 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jmals.2025.409951.1063 | ||
| Authors | ||
| Vignesh K* 1; Sathyasagar kalidoss2; Balaji Kalimuthu1 | ||
| 1Respiratory medicine department, Aarupadai Veedu Medical College & Hospital, Puducherry | ||
| 2Apollo Multi-Speciality Hospital, Chennai Bypass Road Ariyamangalam Area, Old Palpannai, Tiruchirappalli, Tamil Nadu 620010 | ||
| Abstract | ||
| Background: Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to a global pandemic. Mortality and morbidity following COVID-19 were high in patients with preexisting comorbidities like diabetes mellitus, hypertension, underlying lung disease like COPD, etc. Patients with chronic kidney disease have a particularly high chance of acquiring infection as well as high mortality following COVID-19 infection. Materials and Methods:We have done a retrospective observational analysis of 39 chronic kidney disease patients on maintenance hemodialysis admitted at our center with COVID-19 infection. Results: Among the 39 participants, 57% were male and 43% were female, with a mean age of 44.2 years. The primary presenting symptoms were cough (64.1%) and breathlessness (59%). The following factors were associated with mortality: comorbidities like hypertension and COPD, breathlessness during presentation, delayed admission, prolonged hospital stay, dialysis vintage, CORADS score, and requirement of invasive ventilation (statistically significant). 5 patients died during hospitalization (12.8%). Conclusion: The study found that chronic kidney disease (CKD) patients with COVID-19 had an encouraging survival rate of 87.2%. However, delayed diagnosis and admission (within 2 days of symptoms), longer hospital stays (6 days or more), presence of breathlessness, hypertension, longer time on dialysis (3 years or more), patients with more severe lung involvement (higher CO-RADS score), development of multiple organ dysfunction syndrome (MODS), and those requiring invasive mechanical ventilation had a significantly higher risk of death. Interestingly, Remdesivir administration was linked to a decreased risk of mortality. | ||
| Keywords | ||
| Keywords: COVID-19; chronic kidney disease (CKD); hemodialysis; SARS-CoV-2 | ||
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