Effect of local testosterone administration on bone defect healing in orchiectomized rats (Histological and Immunohistochemical study) | ||
| Al-Azhar Assiut Dental Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 10 October 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/aadj.2025.427804.1223 | ||
| Author | ||
| Wael Saleh Ahmed* | ||
| SHOUBRA | ||
| Abstract | ||
| The aim of this study was to evaluate histologically the bone defect’s regeneration after local testosterone administration in orchiectomized (ORX) rats. The experimental part was carried out on 16 adult male albino rats and their weight almost 250 gm., the animals were grouped into 2 equal groups as the following: group I (control) which had not receive the graft, group II (experimental) which had received testosterone loaded on Polyvinylpyrrolidone (PVP) as a carrier material. Specimens were harvested on days 7 and 14 after surgical procedures, prepared and examined histologically by H&E stain. There were wide histological differences between the groups of this study along the different intervals of the study.The histological results demonstrated that there was great acceleration in granulation tissue formation, organization and bone formation in experimental group II which received the graft material. In conclusion, local application of testosterone has a positive regenerative effect on bone defect healing in ORX rats as it could enhance osteoblast cells proliferation and differentiation as well as bone matrix formation and mineralization. | ||
| Keywords | ||
| Keywords: Orchiectomy (ORX); Polyvinylpyrrolidone (PVP); Testosterone | ||
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