Efficacy of Simvastatin Topical Application on Bone Healing around Immediate Dental Implants (Clinical and Radiographic Study) | ||
| Al-Azhar Assiut Dental Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 10 October 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/aadj.2025.419676.1219 | ||
| Authors | ||
| Mohammed Gamal Atef* 1; Mohammad Abdelhamied Shuman2; Mohammed Aly Hassan3 | ||
| 1Egyptian Ministry of Health and population, sohag, Egypt. | ||
| 2Faculty of Dental Medicine - Al-Azhar University, Oral and Maxillofacial Surgery department, Assuit, Egypt | ||
| 3Faculty of Dental Medicine- Al-Azhar University, Oral and Maxillofacial Surgery department, Assiut, Egypt | ||
| Abstract | ||
| Abstract Aim: This study aimed to evaluate the efficacy of simvastatin topical application on bone healing and implant stability in immediate dental implant placement. Subjects and methods: Twenty implants were immediately inserted into fresh extraction sockets in the maxillary and mandibular posterior regions. Patients were divided into two groups: Group I (study group) received immediate implants with allogenic bone graft mixed with simvastatin gel, while Group II (control group) received immediate implants with allogenic bone graft alone. Implant stability was recorded immediately and after 6 months. Bone density and marginal bone loss were assessed using CBCT scans at baseline, 3, 6, and 9 months postoperatively. Clinical parameters, including modified plaque index (mPI), modified bleeding index (mBI), and pain scores, were also recorded. Results: No statistically significant differences were observed between the two groups in bone density, marginal bone loss, or clinical parameters. However, Group I showed a statistically significant increase in secondary implant stability compared to Group II. Conclusion: The application of simvastatin gel combined with bone graft improves implant stability and bone density, enhancing osseointegration in immediate dental implants. Further research with larger sample sizes is recommended to confirm these findings and evaluate long-term effects. | ||
| Keywords | ||
| Dental Implants; Simvastatin; Cone-Beam Computed Tomography; Osseointegration; Bone Grafts | ||
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