The use of Propolis Nonwoven Material (NMS) Sheets to Enhance Wound Healing in Rabbits: A Macroscopic and Histopathological Evaluation | ||
| International Journal of Comprehensive Veterinary Research | ||
| Volume 3, Issue 2, December 2025, Pages 25-38 PDF (1.56 M) | ||
| Document Type: Research article | ||
| DOI: 10.21608/ijcvr.2025.350373.1012 | ||
| Author | ||
| Doaa Barhoum Ali* | ||
| Surgery, Anaesthesiology, and Radiology Faculty of Veterinary Medicine, Sohag University, Egypt | ||
| Abstract | ||
| Propolis, a resinous substance that bees gather from plant exudates and buds and combine with wax and bee enzymes, has biological qualities that make it a great choice for use in pharmaceutical and medical applications. These qualities include anti-inflammatory, antimicrobial, antioxidant, immunomodulatory, and analgesic effects. This study investigated the efficacy of propolis nonwoven material (NMS) sheets in accelerating wound healing in rabbits. Twenty clinically healthy native rabbits underwent surgery to create 1 × 1 cm² excisional wounds on the thoracic region at the right side on their backs, then rabbits were divided into two groups: a propolis treated group that was given Propolis NMS sheets as wound dressings and a control group that received normal saline. Both groups were evaluated macroscopically and histopathologically at 7-, and 14-days post-wound induction. The results indicated that propolis NMS sheets significantly enhanced wound healing, evidenced by improved re-epithelization and reduced wound size. By day 14, wounds treated with propolis showed complete epithelial closure, whereas control wounds were slower to heal and exhibited scabbing. The propolis-treated wounds had fewer inflammatory cells, more collagen, and fibrin, and increased fibroblast and capillary density in comparison with the control group. These results suggested that propolis promotes granulation tissue formation and wound organization, making it a valuable material for managing large open wounds in animals. In conclusion, propolis NMS accelerates wound healing and is recommended for clinical use due to its effectiveness and ease of application. | ||
| Keywords | ||
| Propolis; Nonwoven Material (NMS); Wound Healing; Histopathological Evaluation; Collagen | ||
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