Anti-aging Effects of Natural Bioactive Compounds by Target mTOR: Molecular Docking Approach | ||
| Damanhour Journal of Veterinary Sciences | ||
| Volume 12, Issue 2, December 2024, Pages 55-63 PDF (336.5 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/djvs.2024.302055.1133 | ||
| Authors | ||
| Ali H. El-far* 1; Abdelwahab A. Alsenosy2; Shymaa M. Mokadem1; Manar A. Elshrief1; Shaimaa M. Saafan3; Doaa A. Elsabagh1; Hadeer H. Mohamed1; Mona M. Elghaity1; Shymaa A. Mohamed4 | ||
| 1Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour , Egypt | ||
| 2Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt | ||
| 3Department of Biochemistry, Animal Health Research Institute (AHRI), Damanhour Branch, Agriculture Research Centre (ARC), Damanhour , Egypt | ||
| 4Molecular Biology, Molecular Biology Unit, Medical Technology Centre, Medical Research Institute, Alexandria University, Egypt | ||
| Abstract | ||
| mTOR pathway is involved in the aging process but the understanding of all mechanisms remains needs more extensive research. In the current study, we investigated the molecular docking interactions of catechin, caffeic acid, carvacrol, diosgenin, eugenol, and rutin against mTOR. Results indicated the ability of investigated natural bioactive compounds to interact with mTOR with binding energy of -5.68, -4.87, -4.57, -7.34, -7.34, -9.72 kcal/mol. More in vitro and in vivo experiments are extremely needed to understand the mechanistic role of these natural bioactive compounds to hinder mTOR’s aging process participation. mTOR pathway is involved in the aging process but the understanding of all mechanisms remains needs more extensive research. In the current study, we investigated the molecular docking interactions of catechin, caffeic acid, carvacrol, diosgenin, eugenol, and rutin against mTOR. Results indicated the ability of investigated natural bioactive compounds to interact with mTOR with binding energy of -5.68, -4.87, -4.57, -7.34, -7.34, -9.72 kcal/mol. More in vitro and in vivo experiments are extremely needed to understand the mechanistic role of these natural bioactive compounds to hinder mTOR’s aging process participation. | ||
| Keywords | ||
| Aging; mTOR; Natural bioactive compounds; Molecular docking | ||
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