The Probable Ameliorative Impact of Royal Jelly Supplementation against Aluminium Chloride-Induced Hepatotoxicity in Adult Rats | ||
| البحوث التطبيقية في العلوم والانسانيات | ||
| Volume 2, Issue 1, 2025, Pages 59-74 PDF (1.38 M) | ||
| Document Type: المقالة الأصلية | ||
| DOI: 10.21608/aash.2025.458241 | ||
| Authors | ||
| Alaa Ashraf Abdelmoneim; Amira Ahmed Abdel Moez; Amira Essam Ibrahim; Eman Mohamed El Azab; Asmaa Khaled Mohamed; Esraa Ahmed Mohamed; Esraa Samy Sabet; Hanaa Rizk Aboelwafa | ||
| Prof of Cell Biology and Histology | ||
| Abstract | ||
| Background: Aluminium (Al) is the third abundant element on earth, and it is globally considered as a hidden killer because it is responsible for varied cases of toxicity, health disorders and cancers. Prolonged exposure to Al resulted in its accumulation in many organs, especially the liver inducing different deleterious effects. As a dietary supplement, royal jelly (RJ) is gathered and marketed with the promise of several health benefits due to its compounds Objectives: The current study was performed to explore the probable impact of RJ on AlCl3-induced hepatotoxicity in rats. Methods: Twenty adult rats were equally divided into four groups; control group, RJ-treated group, AlCl3-treated group, and RJ+AlCl3-treated group which were treated for 15 days. Results: Myriad histopathological changes were revealed in the liver tissues of AlCl3-treated rats including destruction of the regular hepatic structure represented by damaged cells possessing vacuolated cytoplasm and altered shaped nuclei which displayed signs of pyknosis, karyorrhexis or karyolysis. Besides, dilatation and congestion of blood vessels. On the other side, a discernible enhancement of the hepatic tissues' histological architecture was revealed in rats concomitantly treated with RJ and AlCl3. Conclusion: Based on its anti-inflammatory, anti-apoptotic, and antioxidant qualities, the current investigation demonstrated that RJ has a protective effect against liver toxicity caused by AlCl3. | ||
| Keywords | ||
| Aluminium Chloride; Royal Jelly; Mammals; Liver; Histology | ||
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