The Impact of Common Analgesics on Kidney Function: An Experimental Study on Rats | ||
| البحوث التطبيقية في العلوم والانسانيات | ||
| Volume 2, Issue 1, 2025, Pages 126-133 PDF (1.25 M) | ||
| Document Type: المقالة الأصلية | ||
| DOI: 10.21608/aash.2025.458250 | ||
| Authors | ||
| Yara Moatez, Yumna Aly; Yasmeen Ahmed; Yasmeen Essam EL dien; Yasmeen Atef; Yasmeen Essam; Asmaa Ahmed Khaled | ||
| Lecturer of Zoology, and Biological and Geological Sciences Department | ||
| Abstract | ||
| This experimental study aimed to evaluate the nephrotoxic and hepatotoxic effects of ibuprofen in male Wistar rats, which is a widely used nonsteroidal anti-inflammatory drug (NSAID). The animals were divided into two groups: a control group and a treatment group that received 800 mg/day ibuprofen orally for 12 consecutive days. Biochemical analysis demonstrated a statistically significant increase (p < 0.01) in the serum urea and creatinine levels in the ibuprofen-treated group, indicating impaired renal function. Additionally, liver enzymes ALT and AST were markedly elevated, suggesting hepatic injury. Histopathological examination of the kidney tissues revealed pronounced structural damage, including glomerular atrophy, tubular necrosis, vacuolation of tubular cells, and congestion of interstitial blood vessels. These findings provide strong evidence that high-dose, short-term administration of ibuprofen can lead to considerable functional and structural damage in both the kidneys and liver. This study highlights the necessity of cautious ibuprofen use, especially in individuals with pre-existing renal or hepatic conditions, and calls for increased awareness of the potential risks associated with unsupervised NSAID consumption. | ||
| Keywords | ||
| Ibuprofen; Kidney function; NSAIDS; Histopathological changes; Wistar Rats | ||
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