Oxidative Stress Responses as A Marker of Toxicity in Mice Exposed to Water Deprivation | ||
| البحوث التطبيقية في العلوم والانسانيات | ||
| Volume 2, Issue 1, 2025, Pages 161-186 PDF (2.14 M) | ||
| Document Type: المقالة الأصلية | ||
| DOI: 10.21608/aash.2025.458253 | ||
| Authors | ||
| Hager Khaled Mohamed Ahmed; Hala Esam Gheta Hussein; Heba Allah Amr Hassan Hafez; Hla salah Ebrahim Mostafa; Manar Mohamed Mohamed shebl; Nada Ahmed Mohamed Abd El Raouf; Nora Hassan Hamed Hamed; asmin Abd El Naser Saaid Refaay; Sally Ramadan Gabr Eid El-Ashry | ||
| Lecturer of Zoology, Department of Biological and Geological Sciences, Faculty of Education, Ain Shams University, | ||
| Abstract | ||
| Water is essential for life, and its deprivation can have severe consequences on human health. Water scarcity is a growing concern globally, affecting millions of people worldwide. Understanding the toxic effects of water deprivation on vital organs is crucial for developing effective strategies to mitigate its impact. This study aimed to investigate the toxicity of water deprivation on oxidative stress in the kidney, histological changes in the kidney, and genotoxicity and cytotoxicity in bone marrow. Forty male albino mice were divided into four groups: control and three water-restricted models (timed, continuous, and intermittent). The results showed significant decreases in antioxidant enzyme activity and increased oxidative stress in the kidney, accompanied by histopathological damage, including tubular necrosis and glomerular hyperplasia. The micronucleus test revealed increased genotoxicity and cytotoxicity in bone marrow, disrupting erythropoiesis. The findings highlight the detrimental effects of water deprivation on kidney and bone marrow function, emphasizing the importance of adequate hydration for maintaining organ integrity. Water deprivation induced significant oxidative stress, renal toxicity, and genotoxic effects, particularly in the intermittent water restriction group. These results underscore the need for awareness about the health effects and toxicity of water deficiency. Based on the study's findings, we recommend prioritizing access to clean drinking water, promoting water conservation practices, and supporting research into innovative solutions for addressing water scarcity. Additionally, developing educational programs to raise awareness about the health risks of water deprivation and fostering community-based initiatives to support affected populations are essential steps towards mitigating these effects. By acknowledging the toxicity of water deprivation and taking proactive measures, we can work towards reducing the associated health risks and promoting overall well-being. Current results have significant implications for public health policy, emphasizing the need for sustainable water management practices and strategies to protect vulnerable populations from the adverse effects of water scarcity. By addressing the health risks associated with water deprivation, we can promote health, well-being, and sustainable development | ||
| Keywords | ||
| Water deprivation; oxidative stress; kidney toxicity; micronucleus test; mice | ||
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