Histological studies on the effect of soyabeans, as a main ingredient in fast food, on fertility of pubescent male mice | ||
| البحوث التطبيقية في العلوم والانسانيات | ||
| Volume 2, Issue 1, 2025, Pages 187-205 PDF (1.98 M) | ||
| Document Type: المقالة الأصلية | ||
| DOI: 10.21608/aash.2025.458256 | ||
| Authors | ||
| Youssef Mahmoud Morad; Abdallah Khalaf Abdelaziz; Michael Magdy philip; Mina Aziz Abdelsayed Aziz; Mahmoud Mohamed Ismail; Youssef Ahmed Noby; Ibrahim Hamdan Abdalmawla; Sahar A. Sabry | ||
| professor of embryology, Department of Biological and Geological Sciences, Faculty of Education, Ain Shams University | ||
| Abstract | ||
| Soybeans, a widely consumed legume, contain phytoestrogens that mimic estrogen and may influence reproductive health. With the increasing prevalence of soy-based ingredients in fast food, concerns have been raised regarding their potential endocrinedisrupting effects, particularly in males during puberty. This study investigates the histological impact of a soy-rich diet on the testes of pubescent male mice, providing insights into its effects on spermatogenesis and testicular morphology. Eighteen male albino mice were divided into three groups: a control group fed a standard diet and two experimental groups fed diets containing 50% and 70% soy protein, respectively, for six weeks. Testicular tissue was collected and analyzed using histological techniques to assess structural and cellular changes. Results demonstrated significant alterations in the testes of soy-fed mice, with higher soy intake correlating with increased disruptions. The 50% soy diet resulted in moderate testicular atrophy, reduced spermatogenesis, and vacuolization of spermatogenic and Sertoli cells. The 70% soy diet caused severe degeneration, characterized by extensive germ cell apoptosis, seminiferous tubule disorganization, and conspicuous alterations of interstitial tissue . Furthermore, increased vascular congestion and immune cell infiltration suggested an inflammatory response, possibly induced by oxidative stress. These findings align with previous research indicating that phytoestrogens can interfere with male reproductive development. The observed testicular damage suggests that prolonged exposure to soy-based diets, particularly in fast food, may have adverse effects on male fertility. Given the global rise in fast-food consumption, further studies are needed to determine long-term reproductive consequences and to assess potential reversibility of these effects. This study highlights the importance of dietary awareness and the need for updated nutritional guidelines to mitigate possible risks associated with excessive soy intake. | ||
| Keywords | ||
| soya beans; testis; male mice- fertility | ||
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