In vivo and molecular docking studies regarded selenium nanoparticles to mitigate diabetic induction in pancreatic tissues of rats influenced by deltamethrin insecticide. | ||
| Advances in Basic and Applied Sciences | ||
| Volume 6, Issue 1, October 2025 PDF (1.47 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/abas.2025.410432.1071 | ||
| Authors | ||
| Mona Ragheb* 1; Afaf Abdelsalam Shalaby1; Ahmed Said Alazzouni2 | ||
| 1Research Institute of Medical Entomology, General Organization of Teaching Hospitals and Institutes, Cairo, Egypt | ||
| 2Zoology Dept. Faculty of Science, Helwan University | ||
| Abstract | ||
| Our aim is to figure out selenium nanoparticles' (SeNPs) mitigating effect on deltamethrin induced diabetes in vivo and via molecular docking methods. Diabetic parameters were examined at both the biochemical and molecular docking levels. Four rat groups were assigned for that objective, oil fed negative control group, SeNPs orally administered group, deltamethrin orally treated group and deltamethrin associated with SeNPs administered group. Administrations lasted for one month without recovery period. The levels of glucose, cholesterol, triglycerides and anti- insulin antibodies were detected in pancreatic tissues as biochemical diabetic indicators. Molecular docking technique was conducted to visualize such influences on the molecular level via Insilco studies. Results implied elevated levels of the biochemical indicators in groups treated with deltamethrin pointing to diabetic induction while, SeNPs intervention were able to mitigate such abnormality. Molecular docking outputs were in line with the biochemical outputs pointing out to the great tendency of SeNPs to bind to the head target proteins addressed for glucose metabolism in cells and insulin reactivity thereby, competing with deltamethrin binding affinities towards such targets. In brief, in vivo and molecular docking approaches confirm the protective role that SeNPs could confer to cells in the purpose of retaining their homeostasis that ensure optimum metabolism of glucose. | ||
| Keywords | ||
| Pancreatic cells; Selenium nanoparticles protective effect; Diabetes mitigation; Molecular docking; diabetes Insilco study | ||
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