Impact of Different Platelet Indices in Epithelial Ovarian Cancer | ||
| The Egyptian Journal of Hospital Medicine | ||
| Volume 101, Issue 1, October 2025, Pages 5073-5078 PDF (468.95 K) | ||
| DOI: 10.21608/ejhm.2025.458360 | ||
| Abstract | ||
| Background: Epithelial ovarian cancer (EOC) remains the most lethal gynecologic malignancy due to its late presentation and high recurrence rate. Despite advances in surgery and chemotherapy, prognosis remains poor, highlighting the need for reliable prognostic biomarkers. Platelet indices, routinely obtained from complete blood counts, have emerged as potential predictors of tumor progression and survival outcomes. Patient and Method: 140 patients with histopathologically confirmed EOC treated at the Oncology Center, Mansoura University. Baseline clinical, radiological, pathological, and hematological data, including platelet indices [mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), and platelet-to-lymphocyte ratio (PLR)], were analyzed for associations with clinicopathological features, treatment response, and survival outcomes. Kaplan–Meier survival curves with log-rank tests were used for disease-free survival (DFS). Results: The mean age at diagnosis was 53.3 years, and most patients were overweight. The majority presented with advanced disease (52.8% in stage III), ascites (70.7%), and omental deposits (47.9%). Elevated PCT, MPV, and PLR were significantly associated with adverse features such as omental deposits and ascites. Thrombocytosis was also correlated with the presence of omental deposits. A low PLR was significantly associated with a reduced risk of recurrence (p=0.042), and the presence of ascites significantly correlated with recurrence (p=0.02). Kaplan–Meier survival analysis demonstrated that altered platelet indices were significantly associated with inferior disease-free survival. Conclusion: Platelet indices are inexpensive and easily accessible biomarkers that provide valuable prognostic information in EOC. Integrating these parameters into routine clinical evaluation may help stratify patients at higher risk of recurrence and guide treatment planning. | ||
| Keywords | ||
| Epithelial Ovarian Cancer; Platelet Indices; Thrombocytosis; Prognosis; Survival; Ascites | ||
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