Unveiling Psychosis; Clinical Presentation, Therapeutic Modalities, and Key Signaling Pathways. | ||
| Archives of Pharmaceutical Sciences Ain Shams University | ||
| Articles in Press, Accepted Manuscript, Available Online from 11 October 2025 PDF (807.46 K) | ||
| Document Type: Review Article | ||
| DOI: 10.21608/aps.2025.349689.1213 | ||
| Authors | ||
| Ashrakt H. Abdelhamid1; Nadine Sameh2; Nancy Mohammed2; Nada A. Abdelfattah2; Nada Ahmed2; Nada Moatamn2; Nermeen Taher2; Nourhan Sameh2; Nourhan Samir2; Naira Emad2; Mina Y. George* 1 | ||
| 1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt | ||
| 2PharmD program, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt | ||
| Abstract | ||
| Individual well-being is greatly influenced by their mental health, affecting their willingness to contribute to society. Mental illnesses might trigger complications that worsen physical health, and cause disabilities that finally may lead to death. In the general population, psychosis is a complicated multivariate neurological condition that is most prevalent in childhood, adolescence, and early adulthood. Recent research has highlighted the significance of psychosis across various healthcare disciplines, including its economic costs and service utilization. Schizophrenia, the predominant type of psychosis, impacts approximately 1% of the global population. Nonetheless, psychotic disorders impose a substantial burden on public health. Psychosis encompasses several forms including numerous neurochemical molecular pathways. Although schizophrenia lacks specific biological markers, several hypotheses such as neurodevelopmental and neurochemical theories have been proposed to elucidate its neuropathology. Such hypotheses may limit the diversity and effectiveness of available drugs for managing psychosis. The primary goals of the management of psychosis include alleviating acute symptoms, enhancing quality of life, and decreasing recurrence rates. This review provides important insights by highlighting key characteristics of psychosis, such as its underlying mechanisms, therapeutic options, and prominent symptoms. | ||
| Keywords | ||
| Psychosis; Schizophrenia; Mental illnesses; pathways; treatment; diagnosis | ||
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