The Effect of Sacubitril / Valsartan on Diastolic function of HFmrEF patients by Tissue Doppler | ||
| Al-Azhar International Medical Journal | ||
| Volume 2025, Issue 6, June 2025 PDF (410.87 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/aimj.2025.446602 | ||
| Authors | ||
| Ahmad Ehab Sadek Al-Adeep1; Moustafa Ibrahim Ibrahim Mokarrab1; Abdelaal Alsayed Abdelrahman Alkhouly1; Hatem Mohammed Mohammed Hassan2 | ||
| 1Cardiology, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt | ||
| 2Cardiology, Cardiology, Health Insurance Organization, Cairo, Egypt | ||
| Abstract | ||
| Background: The left ventricular ejection fraction (EF) plays a critical role in diagnosing heart failure, determining its characteristics, predicting its outcome, and making decisions about treatment. Aim of the work: To examine the impact of Sacubitril / Valsartan on the diastolic function of patients with heart failure and mildly reduced ejection fraction (HFmrEF). Patients and methods: An interventional study targeting patients with HFmrEF for 90 days of follow-up after initiating Sacubitril/Valsartan as part of their standard care was conducted at Suez Health Insurance Cardiology Clinic and Helwan Insurance Hospital. Results: 94 patients (62% males; 60.9 ± 8.84 years) with HFmrEF in NYHA class II–IV were evaluated. A significant improvement in the NYHA class and diastolic function after treatment with standard doses (P<0.001). 63% of the patients had diastolic dysfunction grade 3, and 2% had better grades after 3 months of S–V treatment. Moreover, there was a reduction in E/e′ ratio from (11.8) to (9.9) with non-significant changes in systolic function. Conclusion: In addition to an improvement in NYHA class and symptoms in patients with HFmrEF Sacubitril/Valsartan significantly improved diastolic parameters, This echocardiographic improvement is particularly relevant in those patients with better NYHA class at 3-month follow-up. | ||
| Keywords | ||
| Sacubitril; Valsartan; Diastolic; HFmrEF; Doppler | ||
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