Carbon Monoxide induced toxicity: A literature Review of The Challenges in Early Diagnosis of Cardiotoxicity and Neurotoxicity | ||
| Benha Journal of Applied Sciences | ||
| Volume 10, Issue 5, May 2025, Pages 83-87 PDF (340.64 K) | ||
| Document Type: Original Research Papers | ||
| DOI: 10.21608/bjas.2025.360381.1587 | ||
| Authors | ||
| Alaa A. Marie* ; Ola G. Hagag; Asmaa Y. Hussein; Ibrahim A. Mostafa | ||
| Forensic Medicine and Toxicology Dept., Faculty of Medicine, Benha University | ||
| Abstract | ||
| odorless and non-irritating but highly toxic gas. It results from incomplete combustion of carbonaceous substances. The current method for CO poisoning begins with clinical suspicion and a review of the patient's medical history. It is then confirmed by detecting elevated CO-Hb levels (greater than 10%), which can be measured through invasive blood gas analysis or non-invasive techniques like multi-wave pulse oximetry. Objective: we summarize recent advances in understanding challenges in early diagnosis of CO induced cardiotoxicity and neurotoxicity. Cardiac enzymes, ECG, brain computerized tomography scans are essential markers in diagnosis of CO induced cardiotoxicity and neurotoxicity, while heart-type fatty acid-binding protein and neurogranin are emerging as promising biomarkers. Conclusions: Recent markers are needed for early detection of acute in CO induced cardiotoxicity and neurotoxicity other than traditional markers.: we summarize recent advances in understanding challenges in early diagnosis of CO induced cardiotoxicity and neurotoxicity. Cardiac enzymes, ECG, brain computerized tomography scans are essential markers in diagnosis of CO induced cardiotoxicity and neurotoxicity, while heart-type fatty acid-binding protein and neurogranin are emerging as promising biomarkers. Conclusions: Recent markers are needed for early detection of acute in CO induced cardiotoxicity and neurotoxicity other than traditional markers. | ||
| Keywords | ||
| Carbon monoxide; H-FABP; Neurogranin; Cardiotoxicity; Neurotoxicity | ||
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