Predictive Significance of the Inflammatory Activities and GGT in Hepatocellular Carcinoma Development | ||
| Mansoura Journal of Chemistry | ||
| Volume 68, Issue 5, December 2025, Pages 1-9 PDF (1.15 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjcc.2025.426657.1033 | ||
| Authors | ||
| Amina A Abdelfatah* 1; Magdy M Youssef2; Mohamed Abdel-Wahab3; Mona S Gouida4; Hoda M El-Emshaty5 | ||
| 1Chemistry Department, Biochemistry Division, Faculty of Science, Mansoura University, Mansoura 35516, Egypt. | ||
| 2Prof. of Biochemistry, Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt | ||
| 3Prof. of Gastrointestinal Surgery, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt. | ||
| 4Department of Immunology, Mansoura Children Hospital, Mansoura University, Mansoura 35516, Egypt. | ||
| 5Gastrointestinal Surgery Centre, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt. | ||
| Abstract | ||
| Abstract: This study evaluated whether gamma-glutamyltransferase (GGT) and several non-invasive inflammatory and fibrotic markers could predict the development of hepatocellular carcinoma (HCC). The research included 37 patients with HCC, 45 with liver cirrhosis, and 20 healthy individuals. Patients and Methods: Serum levels of AFP and GGT with the inflammatory markers (AAR, NLR, PLR and Pt) and fibrotic indices (APRI and FIB-4) were investigated in 82 adult HCC and liver cirrhotic patients in addition to 20 healthy individuals as non-disease control (NDC). Results: Our results showed that GGT, along with indices such as AAR, APRI, FIB-4, NLR, and PLR, were significantly elevated in HCC and cirrhotic patients compared to healthy controls. Alpha-fetoprotein (AFP) was the most accurate diagnostic marker (AUC = 0.972). Regression analysis indicated that ALT, INR, and platelet count could serve as early predictors of tumor development. Overall, the findings support the usefulness of combining inflammatory and fibrotic indices with traditional markers to improve early detection of HCC. Conclusion: AAR, NLR, FIB4, APRI and GGT as inflammatory and fibrotic indices play an important role in HCC and liver cirrhosis. ALT, INR and Pt count could be used as early predictors for HCC development. | ||
| Keywords | ||
| AAR; APRI; AFP; FIB4; GGT | ||
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