Stem Cell Therapies for Neurodegenerative Diseases: Emerging Frontiers in Regenerative Medicine | ||
| Frontiers in Scientific Research and Technology | ||
| Articles in Press, Accepted Manuscript, Available Online from 13 October 2025 PDF (638.01 K) | ||
| Document Type: Review Article | ||
| DOI: 10.21608/fsrt.2025.424220.1180 | ||
| Authors | ||
| Asmaa A. Khedr1; Ahmed M. Abdelmaguid2; Ahmed H.A. Elshekh3; Safaa Adel El-Hanfy4; Mohamed M. Elmahdy5; Tomas Hany3; Maryam Ashraf Mostafa6; Nada W. Elsakkary5; Ayatollah Nabil7; Moaz Mohsen8; Khaled M. Alam-Eldein8; Mohamed H.A. Gadelmawla* 9 | ||
| 1Department of zoology and Entomology ,Faculty of Science, Helwan university, Cairo, Egypt. | ||
| 2Department of Biochemistry, Faculty of Science, Helwan University, Cairo, Egypt. | ||
| 3Department of Biochemistry, Faculty of Science, Helwan University, Cairo, Egypt | ||
| 4Faculty of Medicine, Helwan University, Cairo, Egypt | ||
| 5Molecular Biotechnology, Faculty of Science, Helwan University, Cairo, Egypt | ||
| 6Department statistics and computer science, faculty of science, Helwan University, Cairo, Egypt | ||
| 7Department of Biotechnology and Genetic Engineering ,Helawn National University, Cairo | ||
| 8School of Biotechnology, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt | ||
| 9Life Sciences Department, Faculty of Biotechnology, Sinai University, Ismailia, 41636, Egypt | ||
| Abstract | ||
| Neurodegenerative diseases (NDDs) such as Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis represent a growing global health burden with limited therapeutic options. Their progressive course involves oxidative stress, inflammation, protein misfolding, and neuronal loss, and programmed cell death leading to irreversible cognitive and motor decline. Stem cell therapy has emerged as a novel, safe, potential and translational approach offering neuroprotection, anti-inflammatory effects, and neuronal regeneration. Among available cell sources, induced pluripotent stem cells (iPSCs) enable patient-specific, immune-compatible treatments, while mesenchymal stem cells (MSCs) provide neurotrophic support and modulate neuroinflammation, oxidative stress, and apoptosis. Recent preclinical and clinical studies demonstrate encouraging outcomes in restoring neuronal function and slowing disease progression. However, challenges remain in ensuring the safety, integration, and long-term viability of transplanted cells. Future strategies integrating stem cell technologies with artificial intelligence and algorithms personalized and regenerative medicine approaches hold promise for translating these discoveries into effective, disease-modifying therapies for NDDs. | ||
| Keywords | ||
| Stem cell; Neurodegenerative disease; Alzheimer; Parkinson; Pluripotent | ||
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