EFFECT OF VITAMIN E AND SELENIUM ON IMMUNITY, NEUROTRANSMITTER LEVEL, HEPATORENAL FUNCTION, AND MEAT QUALITY IN CHLORPYRIFOS-INTOXICATED EXPERIMENTAL RABBITS | ||
| Assiut Veterinary Medical Journal | ||
| Article 22, Volume 71, Issue 187, October 2025, Pages 271-292 PDF (775.74 K) | ||
| Document Type: Research article | ||
| DOI: 10.21608/avmj.2025.387618.1722 | ||
| Authors | ||
| AZZA M.M. ABDELMOTELEB* 1; AMAL M EL SAYED2; ABEER S. HAFEZ3; HUDA ELSAYED4; AHMED M. MOSTAFA44; MAHA, S. ABD-ELHAFEEZ1 | ||
| 1Biochemistry, Toxicology, and Feed Deficiency Department, Pharmacology Unit, Animal Health Research Institute (AHRI), Agricultural Research Centre (ARC), Dokki, Giza, Egypt. | ||
| 2Food Hygiene and Control Department, Faculty of Veterinary Medicine, Aswan University, Egypt | ||
| 3Immunology Department, Animal Health Research Institute (AHRI), Agricultural Research Centre (ARC), Dokki, Giza, Egypt. | ||
| 4Reference Lab for Safety Analysis of Food of Animal Origin, Animal Health Research Institute (AHRI), Agriculture Research Center (ARC), Giza, Egypt. | ||
| Abstract | ||
| Oxidative stress caused by pesticide exposure is one of the main causes of animal toxicity. Additionally, it degrades the quality of meat and liver tissues. This study investigated how vitamin E and selenium influence immunity, the activity of acetylcholinesterase, liver and kidney health of the chlorpyrifos (CPF) intoxicated rabbits , as well as the quality of their meat and liver over a week of chilling. Each of five groups of the total thirty male New Zealand white rabbits received either corn oil, CPF, CPF and vitamin E, CPF and selenium, or a combination of CPF, vitamin E and selenium for 14 days. The study found that combining vitamin E and selenium with chlorpyrifos treatment in rabbits improved hepatorenal function, normalized levels of immunity (lysozyme, nitric oxide, and tumour necrosis factor-alpha), and prevented drops in serum acetylcholine esterase (AChE) levels. This combination also showed protective effects against oxidative stress (elevation of glutathione (GSH) and superoxide dismutase, SOD) and tissue damage, and lowering CPF residues in fresh tissues to below the maximum residue limit, ensuring food safety for human consumption. The supplementation also improved the quality of meat and liver by ameliorating pH, total volatile basic nitrogen (TVB-N), and thiobarbituric acid (TBA) levels to extend shelf life and reduce potential public health risks associated with pesticides. The study concludes that combined administration of vitamin E, selenium has protective effects against oxidative stress and tissue damage induced by chlorpyrifos and elevates the meat and liver quality of rabbits. | ||
| Keywords | ||
| Pesticides; AChE; antioxidants; meat quality; Residue | ||
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