Effect of Vitamin E and Selenium on Immunity, Neurotransmitter Level, Hepatorenal Function, and Meat Quality | ||
| Assiut Veterinary Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 13 October 2025 | ||
| Document Type: Research article | ||
| DOI: 10.21608/avmj.2025.387618.1722 | ||
| Authors | ||
| Azza M Abdelmoteleb* 1; Maha Sabry Abd Elhafeez2; Abeer sayed Hafez3; Amal mohamed El Sayed4; huda Elsayed5; Ahmed M. Mostafa6 | ||
| 1Biochemistry, Toxicology, and Feed Deficiency Department, Pharmacology Unit, Animal Health Research Institute (AHRI), Agricultural Research Centre (ARC), Dokki, Giza, Egypt | ||
| 2Biochemistry, Toxicology, and Feed Deficiency Department, Pharmacology Unit, Animal Health Research Institute (AHRI), Agricultural Research Centre (ARC), Dokki, Giza, Egypt. | ||
| 3Department of Immunology, Animal Health Research Institute,Agricultural Research Center,Ministry of Agriculture, Dokki, Cairo, Egypt. | ||
| 4faculty ofFood hygiene and Control Department, Faculty Veterinary Medicine, Aswan University, Egypt veterinary medicine | ||
| 5Reference Lab for Safety Analysis of Food of Animal Origin, Animal Health Research Institute (AHRI), Agriculture Research Center (ARC), Giza, Egypt | ||
| 6.Reference Lab for Safety Analysis of Food of Animal Origin, Animal Health Research Institute (AHRI), Agriculture Research Center (ARC), Giza, Egypt. | ||
| Abstract | ||
| Oxidative stress due to pesticide exposure is one of the main causes of animal toxicity. Additionally, it degrades the quality of meat and liver tissues. This study looked at how vitamin E and selenium influence immunity, the activity of acetylcholinesterase, liver and kidney health, and how chlorpyrifos (CPF) spreads in rabbits intoxicated with CPF, as well as the quality of their meat and liver over a week of chilling. Each of five groups of thirty male New Zealand white rabbits received corn oil, CPF, CPF and vitamin E, CPF and selenium, or a combination of CPF, vitamin E and selenium for 14 days. The study found that combining vitamin E and selenium with chlorpyrifos treatment in rabbits improved hepatorenal function biomarkers, normalised levels of immunity indicators (lysozyme, nitric oxide, and tumour necrosis factor-alpha), and prevented drops in serum acetylcholine esterase (AChE) levels. This combination also showed protective effects against oxidative stress (elevation of glutathione (GSH) and superoxide dismutase, SOD) and tissue damage, lowering CPF residues in fresh tissues to below the maximum residue limit, ensuring food safety for human consumption. The supplementation also improved the quality of meat and liver by ameliorating pH, total volatile basic nitrogen (TVB-N), and thiobarbituric acid (TBA) levels to extend shelf life and decline potential public health risks associated with pesticides. The study concludes that combined administration with vitamin E, selenium has protective effects against oxidative stress, and tissue damage induced by chlorpyrifos and elevates the meat and liver quality of rabbits. | ||
| Keywords | ||
| Pesticides; AChE; antioxidants; meat quality; Residue | ||
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