EVALUATION OF SOME VACCINATION PROGRAMS AGAINST NEWCASTLE DISEASE VIRUS IN EXPERIMENTALLY CHALLENGED BROILER CHICKENS | ||
| Assiut Veterinary Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 14 October 2025 | ||
| Document Type: Research article | ||
| DOI: 10.21608/avmj.2025.364281.1606 | ||
| Authors | ||
| AMAAL ABDEL AZIZ GOMAA1; AHMED IBRAHIM AHMED2; MOHAMMED KARMI HUSSEIN3; HAITHAM HAMMAM IBRAHIM* 4 | ||
| 1Department of Poultry and Rabbit Diseases, Faculty of Veterinary Medicine, Aswan University. | ||
| 2Department of Poultry and Rabbit Diseases, Faculty of Veterinary Medicine, South Valley University. | ||
| 3Department of Food Hygiene and Control, Faculty of Veterinary Medicine, Aswan University. | ||
| 4Department of Poultry and Rabbit Diseases, Faculty of Veterinary Medicine, Aswan University | ||
| Abstract | ||
| The objective of the current study was to evaluate the efficiency of different vaccination programs in protecting experimentally challenged broiler chickens against the VV Strain of Newcastle disease virus. Various live and inactivated NDV vaccines were applied during the trial, including HB1, Colone 124, Lasota, and inactivated vaccine. Broiler chicks were divided into 5 groups: the first 3 groups underwent different vaccination programs against NDV, while the other 2 groups (groups 4 and 5) were kept without vaccination to be the control groups. The challenge was done at day 28th of age via intranasal administration of NDV velogenic GVII (NDV/CK/Egypt/F33/2021). Ab titers were determined on days 1,7,14,21,28 and 35 of the experiment. The results of the shedding titers of NDV indicated that the lowest shedding titer was observed in G3, G2 (vaccinated with live and inactivated vaccine), followed on days 3, 5, and 7 post-challenge on the 28th, compared to G1 (vaccinated with live vaccine only). Also, no mortalities (100% protection rate) were recorded in group (3) vaccinated with both live and double shots of killed NDV vaccines, compared to low mortality rates recorded in group (2) vaccinated with live vaccines and one shot of inactivated vaccine and those vaccinated with live vaccines only. The recorded results indicated that ND vaccination programs utilizing both live and double shots of inactivated vaccines were more effective than those depending on a single shot of inactivated vaccine combined with live vaccines, as well as more effective than programs consisting only of live vaccines. | ||
| Keywords | ||
| Vaccination Programs; Live; and Inactivated Vaccines; AB titers; Shedding | ||
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