Cellulose nanocrystals/zinc oxide nanoparticles for Enhanced Antifungal Activity and Flexural Properties of a Heat-cured Acrylic Denture Base Material. | ||
| Advanced Dental Journal | ||
| Volume 7, Issue 4, October 2025, Pages 734-744 PDF (874.17 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/adjc.2024.343170.1677 | ||
| Authors | ||
| Samar Shokri Ibrahim* 1; Farid Abd-Elrheim Badria2; Nahed Galal Bakir3 | ||
| 1Dental Biomaterials, Faculty of Dentistry, October 6 University, Cairo, Egypt | ||
| 2Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Egypt | ||
| 3Biomaterials Department, Faculty of Dentistry, Cairo University, Egypt | ||
| Abstract | ||
| Abstract Aim: To develop an antifungal heat-cured acrylic denture base material with enhanced flexural strength, by incorporating a nanohybrid of nanocellulose and nano zinc oxide into the acrylic. Methodology: Zn2+ was precipitated on the surface of nanocellulose to create a nanohybrid of nanocellulose and nano zinc oxide. The nano zinc oxide, nanocellulose, and nanohybrid were evaluated for particle size and surface morphology using transmission and scanning electron microscopy respectively, and their structure was determined using X-ray diffraction. Two groups of specimens were prepared: unmodified conventional acrylic resin (control), and 1.1% w/w nanohybrid-modified acrylic (intervention). In each group, nine cylindrical specimens were prepared to evaluate antifungal activity using agar dilution method, and eleven bar-shaped specimens for determination of three-point flexural strength and modulus using a Universal Testing Machine. Results: In 1/10 and 1/100 dilutions, incorporating the nanohybrid into the conventional heat-cured acrylic significantly reduced Candida colonies count and led to a notable improvement in both flexural strength (93.38 ± 7.34 MPa for the modified vs. 44.89 ± 4.06 MPa for the unmodified group) and modulus (2257.78 ± 168.37 MPa for the modified vs. 1373.26 ± 209.69 MPa for the unmodified group). Conclusions: Incorporating 1.1% w/w of the nanohybrid into conventional heat-cured acrylic resin may be considered a viable approach to provide antifungal activity and enhance flexural strength and modulus. | ||
| Keywords | ||
| Denture base; Cellulose nanocrystals; Zinc oxide nanoparticles; antifungal activity; flexural strength | ||
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