A Brief Overview about Mesobotox and its Applications in Dermatology | ||
| Zagazig University Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 15 October 2025 | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/zumj.2025.425416.4202 | ||
| Authors | ||
| Salwan Abdelmonem Hegazy* 1; Alshimaa Mohammed Ibrahim2; Heba Selim2 | ||
| 1Faculty of Medicine, Zagazig University | ||
| 2Dermatology, Venereology and Andrology Department, Faculty of Medicine, Zagazig University | ||
| Abstract | ||
| BACKGROUND: Mesobotox, also referred to as intradermal microinjection of diluted botulinum toxin, has emerged as an innovative approach in aesthetic dermatology and facial rejuvenation. Unlike conventional techniques of deep injections, mesobotox involves multiple microdroplet injections into the dermis and superficial subcutaneous layers. This review summarizes the mechanism of action, clinical techniques, therapeutic applications, and safety considerations of mesobotox, while also highlighting future directions for research to widen clinical applications and to optimize treatment outcomes. CONCLUSIONS: Mesobotox primarily influences dermal structures, sebaceous glands, and superficial muscle fibers, resulting in improvement of facial wrinkles and fine lines, pore size reduction, and enhanced skin quality. Furthermore, it offers a versatile application profile, including the management of seborrhea and rosacea, in addition to excessive sweating, keloid scars, and post-acne scarring. The procedure’s minimally invasive nature and favorable safety profile have contributed to its growing popularity, though variability in injection protocols, dosing, and patient selection criteria remain a challenge. Mesobotox use is generally safe, with minimal to no complications, provided safety precautions, such as the injection site and amount, are followed. Future studies are recommended to determine the efficacy and safety limits in the current indications as well as to investigate its therapeutic effect on other skin lesions such as striae. | ||
| Keywords | ||
| Clostridium botulinum Toxin; Neurotoxins; Skin Diseases; Rejuvenation | ||
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