A cross-sectional study clarifying the possible connection Between Irritable Bowel Syndrome and Serum Level of Vitamin D | ||
| African Journal of Gastroenterology and Hepatology | ||
| Volume 8, Issue 1, 2025, Pages 165-174 PDF (446.64 K) | ||
| Document Type: Original Clinical | ||
| DOI: 10.21608/ajgh.2025.407297.1088 | ||
| Authors | ||
| Shimaa Mansour* 1; Fatma Elgebaly1; Nahla Khalaf1; Shimaa Ebrahim1; Ahmed Almedin2; Aymen Elgendy1; Eslam Habba1 | ||
| 1Department of Tropical Medicine and Infectious Diseases, Faculty of Medicine, Tanta University | ||
| 2Physiology Department, Faculty of Medicine, Tanta University | ||
| Abstract | ||
| Background and Aim: Irritable bowel syndrome (IBS) is among the most common chronic functional gastrointestinal disorders, affecting approximately 10%–22% of adults. Vitamin D has been linked to several systemic conditions; however, its exact role in IBS remains unclear. This study aimed to evaluate the possible association between serum vitamin D levels and IBS. Patients and Methods: A cross-sectional study was conducted on 100 participants divided into two groups: Group I included 50 patients diagnosed with IBS according to the Rome IV criteria. At the same time, Group II consisted of 50 healthy subjects serving as controls. Serum vitamin D levels were measured in both groups. Results: A statistically significant difference was observed between the two groups in terms of vitamin D levels (p-value = 0.012). Among IBS patients, 19 (38%) had sufficient vitamin D (>30 ng/mL), while 31 (62%) had subnormal levels. In contrast, 34 (68%) of the control group had sufficient levels, and 16 (32%) were deficient. Conclusions: Vitamin D deficiency may represent a contributing factor in IBS. Therefore, routine assessment of vitamin D levels could be beneficial in patients presenting with IBS. | ||
| Keywords | ||
| Vitamin D; Irritable bowel syndrome; Rome IV | ||
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