Effects Of Platelet Rich Plasma Eye Drops In Corneal Surface Diseases | ||
| Journal of Current Medical Research and Practice | ||
| Articles in Press, Accepted Manuscript, Available Online from 16 October 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jcmrp.2025.426977.1380 | ||
| Authors | ||
| Ahmed A.M Azzam* ; Mohamed Saad Abdelrahman; Mahmoud F. Rateb; Mona Abdallah Abdelrazik; Mohamed G.A Saleh | ||
| Department of Ophthalmology, Faculty of Medicine, Assiut University, Assiut, Egypt | ||
| Abstract | ||
| Background: Ocular surface disorders (OSDs) include conditions such as dry eye disease (DED), persistent epithelial defects (PED), many respond poorly to conventional therapies. Autologous platelet-rich plasma eye drops (PRPEDs), contain growth factors and cytokines that promote corneal healing and epithelial regeneration. Aim: Evaluation of clinical efficacy of PRPEDs in treating various OSDs over a three-month follow up period. Methods: Prospective interventional study included patients with different types of OSDs treated at Assiut University Hospital(AUH). PRPEDs were administered five times daily for one month. Patients were evaluated for best corrected visual acuity(BCVA), tear meniscus height, size of epithelial defects, and subjective symptoms(mainly pain) at baseline, one month, and three months. Results: The study included 70 eyes from 49 patients (mean age: 51.73 ± 16.59 years; 63.3% female) from October 2021 to October 2023. Diagnoses included DED(48.6%), PED(21.4%), ocular cicatricial pemphigoid(15.7%), neurotrophic keratopathy(7.1%), recurrent corneal erosions(2.9%), exposure keratopathy(2.9%), and filamentary keratitis (1.4%). At one month, mean BCVA improved from 0.96 ± 0.37 to 0.59 ± 0.29 logMAR(p < 0.001). Epithelial defects reduced from 70.0% to 6.6%(p < 0.001), with corneal staining dropping from 90.2% to 8.2% of the sample. Tear meniscus height improved to be >0.2 mm in 100% of patients compared to 34.3% at baseline. Subjective symptoms improved in 98.4% of the sample. Recurrence occurred in 13.1% by three months, and complications such as blepharitis and bacterial keratitis were infrequent(1.6%). Conclusion: PRPEDs significantly enhanced epithelial healing and symptomatic relief in OSDs, proving to be an effective biological treatment for resistant OSDs. | ||
| Keywords | ||
| Platelet-rich plasma; Ocular surface disorders; Dry eye disease; Autologous therapy | ||
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