Hepatoprotective Effect of Rosmarinus Officinalis Ethanolic Extract against Damage Induced by Cadmium in Wistar Rats | ||
| Egyptian Journal of Veterinary Sciences | ||
| Articles in Press, Corrected Proof, Available Online from 16 October 2025 PDF (879.78 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejvs.2025.394702.2905 | ||
| Authors | ||
| Said Babou1; Miloud Chakit* 2; Youssef Sqalli-Houssaini3 | ||
| 1Biology and Health laboratory, Faculty of sciences, Ibn Tofail University, Kenitra, Morocco | ||
| 2Biology and Health Laboratory, Faculty of Science, Ibn Tofail University, Kenitra, Morocco. | ||
| 3Biology and Health Laboratory | ||
| Abstract | ||
| Exposure to cadmium (Cd) causes damage to various human and animal organs, including liver. In Morocco, Rosmarinus officinalis (RO) is widely used for treating various liver disorders. The study aimed to assess the effects of RO on liver functions in Wistar female rats exposed to cadmium. 30 Wistar female rats were divided into 5 groups; the control group received orally distilled water, group receiving 1 mg/kg of Cd, group received the ethanolic extract of RO at doses of 200 mg/kg, and the last group received 200 mg/kg of RO and 1 mg/kg of Cd, administered for 8 weeks. At the end of the treatment, the rat blood samples were taken for biochemical analysis, including cholesterol, alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT), glucose, total cholesterol, and triglycerides (TG). Oxidative stress biomarkers, nitric oxide (NO), and the antioxidant enzyme catalase (CAT) were assessed in the liver. The results show Cd exposure induced a significant increase in blood glucose, cholesterol, and triglycerides in rats, reflecting a metabolic disorder of hepatic origin. RO attenuated these alterations and brought the values of the measured parameters closer to those of the control group, suggesting a hepatoprotective and metabolic regulatory effect. The RO ethanolic extract exerts antioxidant activity, manifested by an decrease of NO level and an increase of catalase level in the liver. Rosmarinus officinalis ethanolic extract showed appreciable protective effects on the liver against Cd by decreasing oxidative stress markers, suggesting using Rosmarinus officinalis as a dietary supplement for patients with liver disorders. | ||
| Keywords | ||
| Rosmarinus officinalis; liver; cadmium; oxidant activity; rats | ||
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