Efficacy and Safety of Interventional Radiology Techniques in Malignant Obstructive Jaundice | ||
| Benha Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 16 October 2025 PDF (939.15 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2025.411032.2600 | ||
| Authors | ||
| Eman F. Abdelkhalik1; Ahmed Reda Elneanaey* 2; Hesham E. El sheikh3; Ahmed S. Saafan4; Enas M. Sweed5 | ||
| 1Lecturer of Diagnostic and Interventional Radiology Faculty of Medicine - Banha University | ||
| 2Msc of Radiology Faculty of Medicine - Banha University | ||
| 3Professor and Head of Diagnostic and Interventional Radiology Department Faculty of Medicine - Banha University | ||
| 4Consultant and Head of Diagnostic and Interventional Radiology Department Tanta Cancer Institute - Specialized Medical Center | ||
| 5Assistant Professor of Diagnostic and Interventional Radiology Faculty of Medicine - Banha University | ||
| Abstract | ||
| Background: Malignant obstructive jaundice causes significant morbidity and often precludes surgical cure. Percutaneous interventional radiology (IR) offers minimally invasive decompression, yet comparative data on various IR modalities remain scarce. Methods: In this prospective cohort at Benha University Hospital (September 2025–June 2026), 35 adult patients with inoperable malignant biliary obstruction underwent percutaneous IR drainage. Procedures included internal–external biliary drainage (n = 27), metallic stenting after drainage (n = 3), sequential external then internal–external drainage (n = 2), and external drainage alone (n = 3). We measured total bilirubin before and 15 days post-intervention, recorded procedure-related complications, and analyzed outcomes with significance set at p < 0.05. Results: Mean age was 61.8 ± 11.2 years; 57% male. Overall bilirubin fell from 8.1 ± 2.6 to 2.3 ± 0.8 mg/dL (p < 0.001). The greatest reduction occurred with metallic stenting (∆ 7.2 mg/dL), and the smallest with external drainage alone (∆ 5.1 mg/dL). Complications included biliary hemorrhage (23%), cholangitis (9%), and subcapsular leakage (6%). Conclusion: Interventional radiology techniques provide significant bilirubin reduction with acceptable safety profiles, establishing their role as effective palliative treatment for malignant biliary obstruction. | ||
| Keywords | ||
| malignant biliary obstruction; percutaneous drainage; interventional radiology; biliary stent; bilirubin reduction | ||
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