Value of Fecal Galectin-3 in Assessment of Activity and Remission of Ulcerative Colitis | ||
| Benha Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 16 October 2025 PDF (706.79 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2025.409555.2589 | ||
| Authors | ||
| Mohammed E. El- Shewi1; Yehia S. Younes1; Amira R. Elhawary* 2; Radwa M. Elsharaby3; Yousry E. Aboamer4 | ||
| 1Professor of Hepatology, Gastroenterology and Infectious Diseases Faculty of Medicine- Benha University | ||
| 2M.B.B.Ch., MSc in Tropical Medicine Faculty of Medicine - Ain Shams University | ||
| 3Assistant professor of Clinical Pathology Faculty of Medicine – Tanta University | ||
| 4Educational Assistant Consultant of Tropical Medicine Mahalla Hepatology Teaching Hospital | ||
| Abstract | ||
| Background: Inflammatory bowel diseases (IBD), which primarily include Crohn’s disease (CD), affecting any part of the gastrointestinal tract, and ulcerative colitis (UC), confined to the colon, are characterized by diverse factors influencing disease activity and treatment evaluation. This research aimed to assess Value of fecal Gal-3 in assessment of activity and remission of ulcerative colitis. Methods: This prospective research was conducted on 60 subjects who were divided into two groups; group 1 (including 40 UC cases) and reassessed after 3 months of treatment and group 2 (20 control cases who attended to hospital for endoscopy as an investigation for diarrhea, crampy abdominal pain, urgency, tenesmus and their colonoscopy reveal no abnormality. Results: Fecal calprotectin (FC) and Gal-3 were significantly increased in UC cases. FC decreased after 3 months of treatment but was not reach statistical significance, while there was a significant decrease in fecal Gal-3 in cases after treatment. According to the ROC curve, the best cut off point of fecal Gal-3 level to identify cases with active UC was 0.447 (ng/ml) with 87.5% sensitivity and 85% specificity. And the best cut off point of fecal Gal-3 level to identify cases with remission UC was 0.3165 (ng/ml) with 90% sensitivity and 50% specificity. Conclusion: Fecal Gal-3 could be used as a biomarker for UC disease activity and treatment assessment. | ||
| Keywords | ||
| Fecal Gal-3; Ulcerative Colitis; Inflammatory bowel diseases; Fecal calprotectin | ||
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