Subacute toxicity study of piperonyl butoxide in male mice: histological examination of major organs
Farag, A., Melies, A. (2001). Subacute toxicity study of piperonyl butoxide in male mice: histological examination of major organs. EKB Journal Management System, 9(1), 19-32. doi: 10.21608/jpces.2001.459686
Amina T. Farag; Anisa E. Melies. "Subacute toxicity study of piperonyl butoxide in male mice: histological examination of major organs". EKB Journal Management System, 9, 1, 2001, 19-32. doi: 10.21608/jpces.2001.459686
Farag, A., Melies, A. (2001). 'Subacute toxicity study of piperonyl butoxide in male mice: histological examination of major organs', EKB Journal Management System, 9(1), pp. 19-32. doi: 10.21608/jpces.2001.459686
Farag, A., Melies, A. Subacute toxicity study of piperonyl butoxide in male mice: histological examination of major organs. EKB Journal Management System, 2001; 9(1): 19-32. doi: 10.21608/jpces.2001.459686

Subacute toxicity study of piperonyl butoxide in male mice: histological examination of major organs

Journal of Pest Control and Environmental Sciences
Volume 9, Issue 1, April 2001, Pages 19-32    PDF (612.17 K)
Document Type: Original Article
DOI: 10.21608/jpces.2001.459686
Authors
Amina T. Farag* 1; Anisa E. Melies2
1Department of Pesticide Chemistry, Faculty of Agriculture, Alexandria University
2Department of Histology, Faculty of Medicine, Alexandria University
Abstract
Male CD-I nice (20 mice/group) were administered piperonyl butoxide in the diet at levels of0 (control), 0.1, 0.3, md 0.6% for 4 weeks (5 days/ week). Piperonyl butoxide induced essential hepatotoxicity, renal and brain toxicity with a dose-response relationship. Oedema and disturbance of hepatic architecture in liver, marked widening of interstitial spaces, ranked dilatation of renal tubules with flattened epithelium in kidneys, and patches of increased eosinophilia in the nuropls in brain were observed in the high termed group (0.6%) of piperonyl butoxide. These results indicated that pipronyl butoxide caused essential histological changes in liver, kidney, and brain of1Mle mice.
Statistics
Article View: 2