Value of Urinary Trypsinogen-2 Test in Early Diagnosis of Pancreatitis after Endoscopic Retrograde Cholangiopancreatography (ERCP) | ||
| SVU-International Journal of Medical Sciences | ||
| Volume 8, Issue 2, July 2025, Pages 645-656 PDF (356.44 K) | ||
| Document Type: Original research articles | ||
| DOI: 10.21608/svuijm.2024.334129.2011 | ||
| Authors | ||
| Ahlam Mohammed Sabra1; Hasan Sedeek Mahmoud2; Esraa Abbass Abdallah Ahmed3; Mustafa Ebead* 1; Mohamed Tag-Adeen Said1 | ||
| 1Internal Medicine Department, Faculty of Medicine, South Valley University, Qena , Egypt. | ||
| 2Tropical Medicine Department, Faculty of Medicine, South Valley University, Qena, Egypt. | ||
| 3Clinical Pathology Department, Faculty of Medicine, South Valley University, Qena, Egypt. | ||
| Abstract | ||
| Background: Acute pancreatitis is one of the most serious complications of ERCP. Early diagnosis of post-ERCP pancreatitis (PEP) helps physicians to provide intensive care and possible medical treatment as early as possible. Trypsinogen 2 has recently gained attention as a useful biomarker for diagnosing and assessing the severity of acute PEP. Objectives: to evaluate the role of the urinary trypsinogen-2 test in early diagnosis of PEP and compare its diagnostic value with serum amylase and lipase levels. Patients and methods: We tested the urinary trypsinogen-2 test and serum levels of amylase and lipase in a total of 70 patients with obstructive jaundice after ERCP. Results: PEP was diagnosed in 16 (22.9%) of 70 patients. At cutoff level ( >10.9 ng/ml ) , the sensitivity, specificity, PPV, NPV, and accuracy of urinary trypsinogen-2 test as a predictor of Post-ERCP pancreatitis at 3 hours after ERCP were 93.75%, 94.4 %, 83.3%, 98.1%, and 94.2%, respectively. At the cutoff level (>87 U/L) for amylase, the sensitivity, specificity, PPV , NPV, and accuracy were 75%, 83.3%, 57.1%, 91.8%, and 81.4 % respectively. At the cutoff level (>83 U/L) for lipase, the sensitivity, specificity, PPV, NPV, and accuracy were 75%, 66.7%, 40%, 90%, and 68.57 %, respectively. Conclusions: Urinary TRY-2 is an accurate early marker for diagnosing post-ERCP pancreatitis, with high sensitivity, specificity, and accuracy outperforming serum amylase and lipase, and its strong link to clinical outcomes makes it a valuable noninvasive tool. | ||
| Keywords | ||
| ERCP; Pancreatitis; Urinary trypsinogen-2 test | ||
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