Effects of varying concentrations of iodine intake on thyroid gland in rats | ||
| البحوث التطبيقية في العلوم والانسانيات | ||
| Volume 2, Issue 1, 2025, Pages 91-104 PDF (1.37 M) | ||
| Document Type: المقالة الأصلية | ||
| DOI: 10.21608/aash.2025.459756 | ||
| Authors | ||
| AnaSemon Wahid; Engy Samir; Eman Nour; Aya Hussein; Aya Mohamed; Ganna Mohamed; Habiba Elsayed; Omnia Nasr Abdel-Rahman | ||
| lecturer of Biological and Geological Sciences Department. Ain Shams University, Faculty of Education | ||
| Abstract | ||
| Although iodine is an essential micronutrient needed for the creation of thyroid hormones, too much of it can cause systemic problems and thyroid malfunction. Elevated iodine levels can impact multiple organs and interfere with thyroid function. This study investigates the effects of low and heigh dose of iodine intake on thyroid function, histopathological changes and biochemical alterations in rats. six healthy control rats (150-200g) as group 1, iodine solution was ingested orally to 6 rats at dose 500 μg / kg/day as group 2 and iodine solution at dose (1500 μg /kg/day) was orally administered to 6 rats as group 3. This procedure was performed for 14 days. At the end of this period thyroid function parameters as T3, T4 and TSH levels were recorded in blood samples, and thyroid tissues were also examined histopathologically. Results demonstrated that excessive iodine intake led to thyroidal stress, alterations in thyroxine (T4) triiodothyronine, (T3) levels and TSH, hyperthyroidism in low dose and hypothyroidism in heigh dose group were observed, and deteriorative changes in thyroid tissue were detected. These findings emphasize the possible dangers of excessive iodine intake and highlight the importance of maintaining balanced iodine levels to avoid thyroid and systemic disorder. | ||
| Keywords | ||
| Excess iodine; thyroid hormones; T3; T4; TSH; hypothyroidism; hyperthyroidism | ||
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