Asymptomatic bacteriuria caused by Salmonella Paratyphi B in a pregnant woman with systemic lupus erythematosus, preeclampsia, and sepsis: A rare case report | ||
| Microbes and Infectious Diseases | ||
| Articles in Press, Accepted Manuscript, Available Online from 17 October 2025 | ||
| Document Type: Short Reports (case reports) | ||
| DOI: 10.21608/mid.2025.428674.3277 | ||
| Authors | ||
| Dimas Firman Hidayat* 1; Agung Dwi Wahyu Widodo2 | ||
| 1Study program of Clinical Microbiology, Faculty of Medicine Universitas Airlangga - Dr. Soetomo General Academic Hospital, Jl. Prof Dr Moestopo 47, Surabaya, Indonesia | ||
| 2Department of Clinical Microbiology, Dr. Soetomo General Hospital, Surabaya, Indonesia | ||
| Abstract | ||
| Background: Asymptomatic bacteriuria (ASB) in pregnancy is common, but Salmonella Paratyphi B as the causative organism is extremely rare (<1% of ASB cases), particularly in women with systemic lupus erythematosus (SLE). We report a 37-year-old pregnant woman at 16 weeks’ gestation with chronic hypertension and newly diagnosed SLE who presented with hypertensive emergency, renal impairment, and anemia. Urine culture revealed Salmonella Paratyphi B sensitive to β-lactams and fluoroquinolones, while blood cultures were sterile. Despite appropriate antimicrobial and corticosteroid therapy, her clinical condition deteriorated, with worsening preeclampsia and sepsis. A multidisciplinary team—including obstetrics, rheumatology, nephrology, and microbiology—recommended surgical termination due to nonviable gestation and refractory infection. Following hysterotomy and continued antibiotic therapy, the patient’s renal and hemodynamic parameters improved markedly, and she achieved full recovery. This case underscores the diagnostic and therapeutic challenges of Salmonella ASB in immunocompromised pregnant patients. Early identification, multidisciplinary coordination, and timely obstetric intervention are critical to optimizing maternal outcomes in such complex infections. | ||
| Keywords | ||
| urinary infection; immunocompromised pregnancy; autoimmune disorder; obstetric sepsis; multidisciplinary management | ||
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