Prognostic Value of Measurement of Prothrombin Induced by Vitamin K Deficiency (PIVKA2) and Alpha Feto Protein (AFP) in HCC | ||
| Benha Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 17 October 2025 PDF (698.35 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2025.404116.2541 | ||
| Authors | ||
| Mohamed A. Mohamed1; Hiam A. Eleleimy2; Walaa M. Ibrahim2; Ahmed M. Abdallah2; Mohammed R. Atta* 3 | ||
| 1Assistant Professor of Internal Medicine, Faculty of Medicine, Benha University | ||
| 2Lecturer of Internal Medicine, Faculty of Medicine, Benha University | ||
| 3M.B.B.Ch, Faculty of Medicine, Zagazig University | ||
| Abstract | ||
| Background: Hepatocellular carcinoma (HCC) is a major cause for alarm because it ranks third in cancer-related deaths globally and sixth in the frequency of cancer diagnoses overall. There are three main forms of HCC: viral hepatitis, chronic liver disease, and liver cirrhosis. This study aimed in order to evaluate the relative predictive value of measuring prothrombin time in HCC and alpha fetoprotein (AFP) and prothrombin time when vitamin K is inadequate (PIVKA2). Methods: In this observational research, 96 individuals undergoing therapy for liver cirrhosis at Benha University Hospital were included. Each patient was randomly assigned to one of four groups: Part I: Liver cirrhosis without HCC, and Part ⅏: HCC newly diagnosed. Classification: Group ⅏: HCC patients with metastases and Group ⅎ: HCC patients who began treatment. Results: The ROC analysis was used to determine the optimal cutoff value for distinguishing HCC patients from non-HCC patients. PIVKA2 demonstrated the highest sensitivity (75%) and specificity (88.89%) at 489, with an area under the curve of (0.872).Conclusion: PIVKA-II and AFP are both dependable biomarkers for the diagnosis and prognosis of HCC patients. In terms of the identification of patients with HCC and the prediction of the prognosis for both treated and untreated HCC, both markers exhibited comparable statistical performance. However, PIVKA2 exhibited superior sensitivity and specificity in comparison to AFP at the most optimal cut-off values. | ||
| Keywords | ||
| Alpha Feto Protein; Hepatocellular Carcinoma; Prothrombin Induced by Vitamin K Deficiency | ||
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