The potential role of dill leaves extract in protection against high fat diet-induced nonalcoholic hepatosteatosis in the obese male rats | ||
| Mansoura Journal of Biology | ||
| Volume 60, Issue 7, December 2022, Pages 6-18 PDF (978.11 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjb.2022.459787 | ||
| Authors | ||
| Talal M. Obaid* 1; Rehab A. El-Mougy2; Mamdouh R. El-Sawi3; Azza M. El-Wakf3 | ||
| 1Department of Biology, Faculty of Education, Taiz University, Yemen | ||
| 2Department of chemistry, Faculty of Science, Mansoura University, Egypt | ||
| 3Department of Zoology, Faculty of Science, Mansoura University, Egypt | ||
| Abstract | ||
| This study evaluated whether dill leaves extract (100 mg/kg BW) could protect against obesity and associated liver fatty disease, with a particular focussing on underlying mechanisms. Feeding male rats (170 ± 10 g) on high fat diet (HFD) for 3 months exhibited notable obesity indicated by increased body mass index, abdominal circumference, adiposity index and body weight gain. Results also showed significant elevation of serum glucose, lipids , insulin, leptin and insulin resistance with decreased insulin sensitivity. This goes with significant increases in relative liver weight, hepatic triglycerides, fatty acid synthase, NADPH, oxidative stress indices (CYP2E1, Acyl-CoA oxidase, H2O2, MDA), and serum liver enzymes (AST, ALT, ALP, GGT), accompanied with reduction in endogenous antioxidants (SOD, CAT, GSH), serum total proteins and albumin levels. Increased hepatic proinflammatory cytokines (NF-κβ, TNF-α, IL-1β, IL-6), Kupffer cell markers; CD68 and CD163, and fibrotic mediators (TGF-β1, FN, COL-I) were also noticed, indicating progression of hepatosteatosis. Oral administration of dill leaf extract along with HFD seemed to protect against body weight gain, hepatic fat deposition, oxidative injury, inflammation and fibrotic response. Thus, dill extract can be considered in the future therapy for obesity and associated NASH. | ||
| Keywords | ||
| high fat diet; obesity; fatty liver disease; insulin resistance; fibrosis; dill leaves extract | ||
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