Herbal antibiofilm effects against phenotypically and genotypically detected clinical Methicillin-resistant staphylococcus aureus isolates | ||
| Mansoura Journal of Biology | ||
| Volume 60, Issue 7, December 2022, Pages 19-26 PDF (1.14 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjb.2022.459788 | ||
| Authors | ||
| Nourallah E. Akl* 1; Amira H. EL-Ashry2; Gamal M. Abdel-Fattah1 | ||
| 1Department of Botany, Faculty of Science, Mansoura University, Egypt | ||
| 2Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Egypt. | ||
| Abstract | ||
| This study was conducted to detect the effect of some medicinal plant extracts on the biofilm formation of Methicillin-resistant staphylococcus aureus (MRSA) isolated from patients in Mansoura University Hospitals. Results: Fifty samples (Blood, Wound swab, nasal swab and urine) from patients revealed the total number of isolates were methicillin-resistant staphylococcus aureus (MRSA). Molecular analysis revealed that mec Agene was detected in all isolates. then MRSA isolates were positive for biofilm genes specific (icaA and icaD). Among all herbal plant extracts, Camellia sinensis (green tea) extract was the greater inhibitor of the biofilm formation of MRSA isolates. In this connection, this effect showed the lysis of MRSA cell wall through Transmission Electron Microscope (TEM). Conclusions: Camellia sinensis leaf extracts could be valuable in fighting evolving drug- resistance caused by MRSA. | ||
| Keywords | ||
| Methicillin; Resistant; Phenotypic; Genotypic; Staphylococcus aureus | ||
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